Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland
Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosi...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.794-796 |
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| creator | Poloz, T. L Shkurupiy, V. A |
| description | Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing Ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. Significant differences between all the studied tumors of the thyroid grand with follicular structure were detected. The proposed criteria supplement the postoperative morphological differential diagnosis of thyroid tumors. |
| doi_str_mv | 10.1007/s10517-009-0419-0 |
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The proposed criteria supplement the postoperative morphological differential diagnosis of thyroid tumors.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-009-0419-0</identifier><identifier>PMID: 19513386</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; follicular tumors ; Humans ; immunohistochemistry ; Immunohistochemistry - methods ; Internal Medicine ; Ki-67 Antigen - metabolism ; Laboratory Medicine ; Oncology ; Pathology ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; thyroid ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - metabolism ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Bulletin of experimental biology and medicine, 2008-12, Vol.146 (6), p.794-796</ispartof><rights>Springer Science+Business Media, Inc. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-5bb415ea1b735ae24988f7f68732316fb22528c090b21361f55cc13d0920d08b3</citedby><cites>FETCH-LOGICAL-c393t-5bb415ea1b735ae24988f7f68732316fb22528c090b21361f55cc13d0920d08b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-009-0419-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-009-0419-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19513386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poloz, T. L</creatorcontrib><creatorcontrib>Shkurupiy, V. A</creatorcontrib><title>Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Differential diagnosis of thyroid follicular adenomas, follicular cancer, and papillary cancer with follicular structure was carried out. Proliferation coefficients, probability of atypia, and tumor growth activity were evaluated on the basis of quantitative proportions of proliferation and apoptosis genes expression, derived from indexes of labeled nuclei expressing Ki-67, bcl2, p53 and cytoplasm with expression of bcl2, p53 in cells of these tumors. Significant differences between all the studied tumors of the thyroid grand with follicular structure were detected. The proposed criteria supplement the postoperative morphological differential diagnosis of thyroid tumors.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>follicular tumors</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>Internal Medicine</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Laboratory Medicine</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>thyroid</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU9v3CAQxVGVqtmm_QC9pFYOvbmdAYPxMdr8lSK1UjZnhDHsktgmBfuQb182XilSDr2AmPm9NyMeId8QfiJA_SshcKxLgKaECvPxgayQ16yUlOIRWUGGykpKeUw-p_S4f4LAT-QYG46MSbEiT3_CZMfJ695P3qYiuOLCO2fjUixuh2Eew86nKZidHbzJtQuvt2NI_pW-D4MtrkLfezP3OhabeQjxtTPtbLHZvcTgu-K612P3hXx0uk_26-E-IQ9Xl5v1TXn3-_p2fX5XGtawqeRtWyG3GtuacW1p1UjpaidkzShD4VpKOZUGGmgpMoGOc2OQddBQ6EC27IT8WHyfY_g72zSpwSdj-7yDDXNSQtRYSU4zePYOfAxzHPNuKjtXnDUgMoQLZGJIKVqnnqMfdHxRCGofg1piUDkGtY9BQdacHozndrDdm-Lw7xmgC5Bya9za-Db5f67fF5HTQelt9Ek93FNABigY0pqxf5Bdm0c</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Poloz, T. 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| subjects | Biomedical and Life Sciences Biomedicine Cell Biology follicular tumors Humans immunohistochemistry Immunohistochemistry - methods Internal Medicine Ki-67 Antigen - metabolism Laboratory Medicine Oncology Pathology Proto-Oncogene Proteins c-bcl-2 - metabolism thyroid Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism Tumor Suppressor Protein p53 - metabolism |
| title | Potentialities of Differential Immunohistochemical Diagnosis of Some Follicular Tumors of the Thyroid Gland |
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