In Vitro Effect of Oxidized Dextrans on Peritoneal Cells

We studied the dependence of in vitro dextran biocompatibility on the method of oxidation of 35-kDa dextran. The biocompatibility of dextran oxidized with potassium permanganate was higher compared to that obtained by radiochemical oxidation. It was related to the formation of peroxide compounds dur...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-12, Vol.146 (6), p.868-870
Hauptverfasser:	Shkurupiy, V. A, Arkhipov, S. A, Troitsky, A. V, Luzgina, N. G, Zaikovskaja, M. V, Gulyaeva, E. P, Bistrova, T. N, Ufimceva, E. G, Iljin, D. A, Akhramenko, E. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - chemistry Anticoagulants - pharmacology biocompatibility Biomedical and Life Sciences Biomedicine Cell Adhesion - drug effects Cell Biology Cell Survival - drug effects Cells, Cultured Cytology Dextrans - chemistry Dextrans - pharmacology Internal Medicine Laboratory Medicine macrophages Male Mice Mice, Inbred BALB C Oxidation-Reduction oxidized dextran Pathology peritoneal cells Peritoneum - cytology Potassium Permanganate - chemistry Radiochemistry
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Zusammenfassung:	We studied the dependence of in vitro dextran biocompatibility on the method of oxidation of 35-kDa dextran. The biocompatibility of dextran oxidized with potassium permanganate was higher compared to that obtained by radiochemical oxidation. It was related to the formation of peroxide compounds during radiochemical oxidation.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-009-0427-0