Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid

Lysophosphatidic acid (LPA) is a bioactive phospholipid having growth factor-like activity on fibroblasts and is involved in cardiovascular diseases such as hypertension and heart failure by inducing vascular remodeling, characterized by fibroblast proliferation and migration in adventitia. Among va...

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Veröffentlicht in:	Regulatory peptides 2004-09, Vol.121 (1), p.49-56
Hauptverfasser:	Yang, Jing-Hui, Jiang, Wei, Pan, Chun-Shui, Qi, Yong-Feng, Wu, Qi-Zhuan, Pang, Yong-Zheng, Tang, Chao-Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Adventitia Animals Biological and medical sciences Cell Proliferation - drug effects Connective Tissue - drug effects Connective Tissue - growth & development Connective Tissue - secretion Cyclic AMP - metabolism DNA - biosynthesis Dose-Response Relationship, Drug Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Lysophosphatidic acid Lysophospholipids - antagonists & inhibitors Lysophospholipids - pharmacology Mitogen-Activated Protein Kinases - metabolism Paracrine Communication - drug effects Peptides - genetics Peptides - pharmacology Peptides - physiology Peptides - secretion Proliferation Rats Vertebrates: endocrinology
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