Toll-like receptor agonists and invariant natural killer T-cells enhance antibody-dependent cell-mediated cytotoxicity (ADCC)

Abstract huHMFG-1 (AS1402) is a humanised IgG1 against MUC1, which exerts tumour cell killing through antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells. Here, we explored the capacity of invariant NKT (iNKT) cells, which are known to activate NK cells, and toll-li...

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Veröffentlicht in:	Cancer letters 2008-12, Vol.272 (1), p.70-76
Hauptverfasser:	Moreno, María, Mol, Berber M, Mensdorff-Pouilly, Silvia von, Verheijen, René H.M, von Blomberg, B.Mary E, van den Eertwegh, Alfons J.M, Scheper, Rik J, Bontkes, Hetty J
Format:	Artikel
Sprache:	eng
Schlagworte:	ADCC Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody-Dependent Cell Cytotoxicity - immunology Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - immunology Blood banks Cancer Cytotoxicity Flow Cytometry Granzymes - immunology Hematology, Oncology and Palliative Medicine Human Humans Immune system Immunoglobulin G - pharmacology Immunotherapy - methods Invariant NKT cells Killer Cells, Natural - immunology Lectins, C-Type Leukocytes, Mononuclear - immunology Ligands Lymphocyte Activation Mice Mucin-1 - immunology Natural Killer T-Cells - immunology NK cells T cell receptors Toll-like receptor Toll-Like Receptors - immunology
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