Osteomalacia and giant cell tumor: a rare case
Oncogenic octeomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia and normocalcemia. We have investigated the mechanism by which a giant cell tumor of bone cau...
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| Veröffentlicht in: | Tunisie Medicale 2008-09, Vol.86 (9), p.836-838 |
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| creator | Sehli, Hela Daoud, Lilia Ben Mbarek, Rim Ghorbel, Rim Ben Abdelghani, Kaouther Charfi, Hichem Cheour, Ilhem Tarhouni, Lamjed Sellami, Slaheddine |
| description | Oncogenic octeomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia and normocalcemia.
We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.
A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.
oncogenic osteomalacia can be a form of vitamin-D-refractory osteomalacia due to altered vitamin D3 metabolism. |
| format | Article |
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We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.
A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.
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We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.
A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.
oncogenic osteomalacia can be a form of vitamin-D-refractory osteomalacia due to altered vitamin D3 metabolism.</description><subject>Bone Neoplasms - complications</subject><subject>Female</subject><subject>Giant Cell Tumor of Bone - complications</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Osteomalacia - etiology</subject><subject>Osteomalacia - pathology</subject><issn>0041-4131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j7lqAzEURVUkxMbxLxhV6SboaR2lCyYbGNy4H7Q8hTGzRZop8vdxiHOb2xwO996QNWMSKgkCVmRbypldohlYBXdkBVYabmqzJo_HMuPYu86F1lE3RPrZumGmAbuOzks_5ifqaHYZaXAF78ltcl3B7bU35PT6ctq_V4fj28f--VBNSppKeS7rKCKznhkMwieoPTIuuRURNfM6clCWGSXAaGmT8QhBMAhJ8MSS2JCHP-2Ux68Fy9z0bfmd5AYcl9JobYCr2lzA3RVcfI-xmXLbu_zd_B8UP3mVSdw</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Sehli, Hela</creator><creator>Daoud, Lilia</creator><creator>Ben Mbarek, Rim</creator><creator>Ghorbel, Rim</creator><creator>Ben Abdelghani, Kaouther</creator><creator>Charfi, Hichem</creator><creator>Cheour, Ilhem</creator><creator>Tarhouni, Lamjed</creator><creator>Sellami, Slaheddine</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200809</creationdate><title>Osteomalacia and giant cell tumor: a rare case</title><author>Sehli, Hela ; Daoud, Lilia ; Ben Mbarek, Rim ; Ghorbel, Rim ; Ben Abdelghani, Kaouther ; Charfi, Hichem ; Cheour, Ilhem ; Tarhouni, Lamjed ; Sellami, Slaheddine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p547-5b248d3d09b07ec3bf18be024293de60b6d2159075317649f7be1c301cf32f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2008</creationdate><topic>Bone Neoplasms - complications</topic><topic>Female</topic><topic>Giant Cell Tumor of Bone - complications</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Osteomalacia - etiology</topic><topic>Osteomalacia - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sehli, Hela</creatorcontrib><creatorcontrib>Daoud, Lilia</creatorcontrib><creatorcontrib>Ben Mbarek, Rim</creatorcontrib><creatorcontrib>Ghorbel, Rim</creatorcontrib><creatorcontrib>Ben Abdelghani, Kaouther</creatorcontrib><creatorcontrib>Charfi, Hichem</creatorcontrib><creatorcontrib>Cheour, Ilhem</creatorcontrib><creatorcontrib>Tarhouni, Lamjed</creatorcontrib><creatorcontrib>Sellami, Slaheddine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Tunisie Medicale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sehli, Hela</au><au>Daoud, Lilia</au><au>Ben Mbarek, Rim</au><au>Ghorbel, Rim</au><au>Ben Abdelghani, Kaouther</au><au>Charfi, Hichem</au><au>Cheour, Ilhem</au><au>Tarhouni, Lamjed</au><au>Sellami, Slaheddine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteomalacia and giant cell tumor: a rare case</atitle><jtitle>Tunisie Medicale</jtitle><addtitle>Tunis Med</addtitle><date>2008-09</date><risdate>2008</risdate><volume>86</volume><issue>9</issue><spage>836</spage><epage>838</epage><pages>836-838</pages><issn>0041-4131</issn><abstract>Oncogenic octeomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia and normocalcemia.
We have investigated the mechanism by which a giant cell tumor of bone caused biopsy-proved osteomalacia in a 50-year-old woman.
A 50-year-old woman presented with generalized bone and pelvicrural pain, associated with fatiguability and muscle weakness. The diagnosis of osteomalacia was retained, associated with a giant cell tumor. The coexistence of giant cell tumor of bone and osteomalacia suggested the diagnosis of oncogenic osteomalacia. Resolution of the biochemical abnormalities of the syndrome after tumor resection, established this diagnosis.
oncogenic osteomalacia can be a form of vitamin-D-refractory osteomalacia due to altered vitamin D3 metabolism.</abstract><cop>Tunisia</cop><pmid>19472787</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Tunisie Medicale, 2008-09, Vol.86 (9), p.836-838 |
| issn | 0041-4131 |
| language | fre |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bone Neoplasms - complications Female Giant Cell Tumor of Bone - complications Humans Middle Aged Osteomalacia - etiology Osteomalacia - pathology |
| title | Osteomalacia and giant cell tumor: a rare case |
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