β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity
Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear. Muscle sympathetic nerve activity (MSNA), H...
Gespeichert in:
Veröffentlicht in: | Medicine and science in sports and exercise 2008-11, Vol.40 (11), p.1932-1938 |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1938 |
---|---|
container_issue | 11 |
container_start_page | 1932 |
container_title | Medicine and science in sports and exercise |
container_volume | 40 |
creator | BELOKA, Sofia GUJIC, Marko DEBOECK, Gael NISET, Georges CIARKA, Agnieszka ARGACHA, Jean-Francois ADAMOPOULOS, Dionysios VAN DE BORNE, Philippe NAEIJE, Robert |
description | Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear.
Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and end-tidal PCO2 (PetCO2) were measured in 14 healthy young adults after 1 wk of beta1-receptor blockade with bisoprolol 5 mg x d(-1) versus placebo after a double-blind, placebo-controlled, randomized crossover design. The MSNA and the ventilatory responses to hyperoxic hypercapnia (7% CO2 in O2), DeltaV(E)/DeltaPetCO2, and isocapnic hypoxia (10% O2 in N2), DeltaV(E)/DeltaSpO2, and to an isometric muscle contraction followed by a local circulatory arrest (metaboreflex) were determined at rest followed by an incremental cardiopulmonary exercise test.
Bisoprolol did not change the V(E) and MSNA responses to hypercapnia, hyperoxia, or isometric muscle contraction or ischemia. Bisoprolol decreased maximum O2 uptake (P < 0.05), workload (P < 0.05), and HR (P < 0.0001) and both V(E)/VO2 and V(E)/VCO2 slopes (P < 0.05).
These results suggest that decreased aerobic exercise capacity after intake of beta-blockers is accompanied by decreased ventilation at any metabolic rate. However, this occurs without detectable change in the sympathetic nervous system tone or in metabo- or chemosensitivity and is therefore probably of hemodynamic origin. |
doi_str_mv | 10.1249/MSS.0b013e31817fbe11 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_66712482</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66712482</sourcerecordid><originalsourceid>FETCH-LOGICAL-p239t-eaacbc84e479d15ed96d7a0fc8a628693be04132e6da9f2e97ecf4df034e00e93</originalsourceid><addsrcrecordid>eNo90N1KwzAcBfAgipvTNxDpjd51Jk3aJJezzA_YUJhelzT5R6ttU5MWttfyQXwmC06vzs2PA-cgdE7wnCRMXq83mzkuMaFAiSDclkDIAZqSlOIYU5IeoikmMo0loWSCTkJ4xxhzSskxmhAhWCozPkVP31_xwnhowb9WOrqpnf5QBiLVmmgNvSpdnL9B4zzYGrZR7treV-XQV64NUe-i5Ra8rgJEueqUrvrdKTqyqg5wts8ZerldPuf38erx7iFfrOIuobKPQSldasGAcWlICkZmhitstVBZIjJJS8CM0AQyo6RNQHLQlhmLKQOMQdIZuvrt7bz7HCD0RVMFDXWtWnBDKLKMjzeJZIQXeziUDZii81Wj_K74-2AEl3uggla19aodF_27BHOBJWP0B_d3boo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66712482</pqid></control><display><type>article</type><title>β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Journals@Ovid Complete</source><creator>BELOKA, Sofia ; GUJIC, Marko ; DEBOECK, Gael ; NISET, Georges ; CIARKA, Agnieszka ; ARGACHA, Jean-Francois ; ADAMOPOULOS, Dionysios ; VAN DE BORNE, Philippe ; NAEIJE, Robert</creator><creatorcontrib>BELOKA, Sofia ; GUJIC, Marko ; DEBOECK, Gael ; NISET, Georges ; CIARKA, Agnieszka ; ARGACHA, Jean-Francois ; ADAMOPOULOS, Dionysios ; VAN DE BORNE, Philippe ; NAEIJE, Robert</creatorcontrib><description>Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear.
Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and end-tidal PCO2 (PetCO2) were measured in 14 healthy young adults after 1 wk of beta1-receptor blockade with bisoprolol 5 mg x d(-1) versus placebo after a double-blind, placebo-controlled, randomized crossover design. The MSNA and the ventilatory responses to hyperoxic hypercapnia (7% CO2 in O2), DeltaV(E)/DeltaPetCO2, and isocapnic hypoxia (10% O2 in N2), DeltaV(E)/DeltaSpO2, and to an isometric muscle contraction followed by a local circulatory arrest (metaboreflex) were determined at rest followed by an incremental cardiopulmonary exercise test.
Bisoprolol did not change the V(E) and MSNA responses to hypercapnia, hyperoxia, or isometric muscle contraction or ischemia. Bisoprolol decreased maximum O2 uptake (P < 0.05), workload (P < 0.05), and HR (P < 0.0001) and both V(E)/VO2 and V(E)/VCO2 slopes (P < 0.05).
These results suggest that decreased aerobic exercise capacity after intake of beta-blockers is accompanied by decreased ventilation at any metabolic rate. However, this occurs without detectable change in the sympathetic nervous system tone or in metabo- or chemosensitivity and is therefore probably of hemodynamic origin.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/MSS.0b013e31817fbe11</identifier><identifier>PMID: 18845967</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adrenergic beta-Antagonists - pharmacology ; Adult ; Biological and medical sciences ; Cross-Over Studies ; Double-Blind Method ; Exercise - physiology ; Fundamental and applied biological sciences. Psychology ; Hemodynamics - drug effects ; Humans ; Male ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Oxygen Consumption ; Placebos ; Space life sciences ; Sympathetic Nervous System - drug effects ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports ; Young Adult</subject><ispartof>Medicine and science in sports and exercise, 2008-11, Vol.40 (11), p.1932-1938</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20780944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18845967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BELOKA, Sofia</creatorcontrib><creatorcontrib>GUJIC, Marko</creatorcontrib><creatorcontrib>DEBOECK, Gael</creatorcontrib><creatorcontrib>NISET, Georges</creatorcontrib><creatorcontrib>CIARKA, Agnieszka</creatorcontrib><creatorcontrib>ARGACHA, Jean-Francois</creatorcontrib><creatorcontrib>ADAMOPOULOS, Dionysios</creatorcontrib><creatorcontrib>VAN DE BORNE, Philippe</creatorcontrib><creatorcontrib>NAEIJE, Robert</creatorcontrib><title>β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear.
Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and end-tidal PCO2 (PetCO2) were measured in 14 healthy young adults after 1 wk of beta1-receptor blockade with bisoprolol 5 mg x d(-1) versus placebo after a double-blind, placebo-controlled, randomized crossover design. The MSNA and the ventilatory responses to hyperoxic hypercapnia (7% CO2 in O2), DeltaV(E)/DeltaPetCO2, and isocapnic hypoxia (10% O2 in N2), DeltaV(E)/DeltaSpO2, and to an isometric muscle contraction followed by a local circulatory arrest (metaboreflex) were determined at rest followed by an incremental cardiopulmonary exercise test.
Bisoprolol did not change the V(E) and MSNA responses to hypercapnia, hyperoxia, or isometric muscle contraction or ischemia. Bisoprolol decreased maximum O2 uptake (P < 0.05), workload (P < 0.05), and HR (P < 0.0001) and both V(E)/VO2 and V(E)/VCO2 slopes (P < 0.05).
These results suggest that decreased aerobic exercise capacity after intake of beta-blockers is accompanied by decreased ventilation at any metabolic rate. However, this occurs without detectable change in the sympathetic nervous system tone or in metabo- or chemosensitivity and is therefore probably of hemodynamic origin.</description><subject>Adolescent</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Exercise - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Oxygen Consumption</subject><subject>Placebos</subject><subject>Space life sciences</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><subject>Young Adult</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90N1KwzAcBfAgipvTNxDpjd51Jk3aJJezzA_YUJhelzT5R6ttU5MWttfyQXwmC06vzs2PA-cgdE7wnCRMXq83mzkuMaFAiSDclkDIAZqSlOIYU5IeoikmMo0loWSCTkJ4xxhzSskxmhAhWCozPkVP31_xwnhowb9WOrqpnf5QBiLVmmgNvSpdnL9B4zzYGrZR7treV-XQV64NUe-i5Ra8rgJEueqUrvrdKTqyqg5wts8ZerldPuf38erx7iFfrOIuobKPQSldasGAcWlICkZmhitstVBZIjJJS8CM0AQyo6RNQHLQlhmLKQOMQdIZuvrt7bz7HCD0RVMFDXWtWnBDKLKMjzeJZIQXeziUDZii81Wj_K74-2AEl3uggla19aodF_27BHOBJWP0B_d3boo</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>BELOKA, Sofia</creator><creator>GUJIC, Marko</creator><creator>DEBOECK, Gael</creator><creator>NISET, Georges</creator><creator>CIARKA, Agnieszka</creator><creator>ARGACHA, Jean-Francois</creator><creator>ADAMOPOULOS, Dionysios</creator><creator>VAN DE BORNE, Philippe</creator><creator>NAEIJE, Robert</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity</title><author>BELOKA, Sofia ; GUJIC, Marko ; DEBOECK, Gael ; NISET, Georges ; CIARKA, Agnieszka ; ARGACHA, Jean-Francois ; ADAMOPOULOS, Dionysios ; VAN DE BORNE, Philippe ; NAEIJE, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-eaacbc84e479d15ed96d7a0fc8a628693be04132e6da9f2e97ecf4df034e00e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>Exercise - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Oxygen Consumption</topic><topic>Placebos</topic><topic>Space life sciences</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BELOKA, Sofia</creatorcontrib><creatorcontrib>GUJIC, Marko</creatorcontrib><creatorcontrib>DEBOECK, Gael</creatorcontrib><creatorcontrib>NISET, Georges</creatorcontrib><creatorcontrib>CIARKA, Agnieszka</creatorcontrib><creatorcontrib>ARGACHA, Jean-Francois</creatorcontrib><creatorcontrib>ADAMOPOULOS, Dionysios</creatorcontrib><creatorcontrib>VAN DE BORNE, Philippe</creatorcontrib><creatorcontrib>NAEIJE, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BELOKA, Sofia</au><au>GUJIC, Marko</au><au>DEBOECK, Gael</au><au>NISET, Georges</au><au>CIARKA, Agnieszka</au><au>ARGACHA, Jean-Francois</au><au>ADAMOPOULOS, Dionysios</au><au>VAN DE BORNE, Philippe</au><au>NAEIJE, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>40</volume><issue>11</issue><spage>1932</spage><epage>1938</epage><pages>1932-1938</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>Exercise-induced dyspnea in patients with cardiopulmonary diseases may be related to sympathetic nervous system activation, with increased metabo- and/or chemosensitivities. Whether this mechanism plays a role in exercising normal subjects remains unclear.
Muscle sympathetic nerve activity (MSNA), HR, ventilation (V(E)), O2 saturation (SpO2), and end-tidal PCO2 (PetCO2) were measured in 14 healthy young adults after 1 wk of beta1-receptor blockade with bisoprolol 5 mg x d(-1) versus placebo after a double-blind, placebo-controlled, randomized crossover design. The MSNA and the ventilatory responses to hyperoxic hypercapnia (7% CO2 in O2), DeltaV(E)/DeltaPetCO2, and isocapnic hypoxia (10% O2 in N2), DeltaV(E)/DeltaSpO2, and to an isometric muscle contraction followed by a local circulatory arrest (metaboreflex) were determined at rest followed by an incremental cardiopulmonary exercise test.
Bisoprolol did not change the V(E) and MSNA responses to hypercapnia, hyperoxia, or isometric muscle contraction or ischemia. Bisoprolol decreased maximum O2 uptake (P < 0.05), workload (P < 0.05), and HR (P < 0.0001) and both V(E)/VO2 and V(E)/VCO2 slopes (P < 0.05).
These results suggest that decreased aerobic exercise capacity after intake of beta-blockers is accompanied by decreased ventilation at any metabolic rate. However, this occurs without detectable change in the sympathetic nervous system tone or in metabo- or chemosensitivity and is therefore probably of hemodynamic origin.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18845967</pmid><doi>10.1249/MSS.0b013e31817fbe11</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0195-9131 |
ispartof | Medicine and science in sports and exercise, 2008-11, Vol.40 (11), p.1932-1938 |
issn | 0195-9131 1530-0315 |
language | eng |
recordid | cdi_proquest_miscellaneous_66712482 |
source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete |
subjects | Adolescent Adrenergic beta-Antagonists - pharmacology Adult Biological and medical sciences Cross-Over Studies Double-Blind Method Exercise - physiology Fundamental and applied biological sciences. Psychology Hemodynamics - drug effects Humans Male Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oxygen Consumption Placebos Space life sciences Sympathetic Nervous System - drug effects Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Young Adult |
title | β-Adrenergic Blockade and Metabo-Chemoreflex Contributions to Exercise Capacity |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T09%3A35%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%CE%B2-Adrenergic%20Blockade%20and%20Metabo-Chemoreflex%20Contributions%20to%20Exercise%20Capacity&rft.jtitle=Medicine%20and%20science%20in%20sports%20and%20exercise&rft.au=BELOKA,%20Sofia&rft.date=2008-11-01&rft.volume=40&rft.issue=11&rft.spage=1932&rft.epage=1938&rft.pages=1932-1938&rft.issn=0195-9131&rft.eissn=1530-0315&rft.coden=MSPEDA&rft_id=info:doi/10.1249/MSS.0b013e31817fbe11&rft_dat=%3Cproquest_pubme%3E66712482%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66712482&rft_id=info:pmid/18845967&rfr_iscdi=true |