Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

Myeloperoxidase, a heme protein expressed by professional phagocytic cells, generates an array of oxidants which are proposed to contribute to tissue damage during inflammation. We now report that enzymatically active myeloperoxidase and its characteristic amino acid oxidation products are present i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2004-08, Vol.90 (3), p.724-733
Hauptverfasser:	Green, Pattie S., Mendez, Armando J., Jacob, Jason S., Crowley, Jan R., Growdon, Whit, Hyman, Bradley T., Heinecke, Jay W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐chlorotyrosine Aged Alzheimer Disease - enzymology Alzheimer Disease - etiology Alzheimer Disease - pathology Alzheimer's disease Animals Biological and medical sciences Brain - enzymology Brain - pathology Cells, Cultured Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Hippocampus - enzymology Hippocampus - pathology Humans Medical sciences myeloperoxidase Neocortex - enzymology Neocortex - pathology Neurology Neurons - cytology Neurons - enzymology Neurons - pathology o,o′‐dityrosine Oxidative Stress Peroxidase - genetics Peroxidase - metabolism Plaque, Amyloid - enzymology Plaque, Amyloid - pathology Rats RNA, Messenger - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!