Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival

Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is a tumor necrosis factor superfamily member that induces apoptosis through the death receptors DR4 and/or DR5 in various cancer cell types but not in most normal cells. Several lung cancer cell lines express DR4 and...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-07, Vol.64 (14), p.4900-4905
Hauptverfasser:	HONGKUI JIN, RENHUI YANG, SHARON FONG, TOTPAL, Klara, LAWRENCE, David, ZHONG ZHENG, ROSS, Jed, KOEPPEN, Hartmut, SCHWALL, Ralph, ASHKENAZI, Avi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Regulatory Proteins Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - pathology Cell Division - drug effects Cell Line, Tumor Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - pathology Medical sciences Membrane Glycoproteins - administration & dosage Membrane Glycoproteins - pharmacology Mice Mice, Nude Pharmacology. Drug treatments Recombinant Proteins - pharmacology TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - pharmacology Tumors Xenograft Model Antitumor Assays
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