Proteome and Transcriptome Analysis of Retinoic Acid-Induced Differentiation of Human Acute Promyelocytic Leukemia Cells, NB4

Acute promyelocytic leukemia (APL) is characterized by a translocation t(15:17) that fuses the retinoic acid receptor gene with the promyelocytic gene, which blocks differentiation to normal granulocytes. NB4 cells, derived from human acute promyelocytic leukemia, display this genotype and phenotype...

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Veröffentlicht in:	Journal of proteome research 2004-05, Vol.3 (3), p.627-635
Hauptverfasser:	Wang, Daojing, Jensen, Ronald, Gendeh, Gurmil, Williams, Katherine, Pallavicini, Maria G
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - drug effects Cell Differentiation - physiology Electrophoresis, Gel, Two-Dimensional Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Granulocytes - cytology Granulocytes - drug effects Granulocytes - metabolism Humans Leukemia, Promyelocytic, Acute - metabolism Proteome Receptors, Retinoic Acid - metabolism RNA, Messenger - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tretinoin - pharmacology Tumor Cells, Cultured
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