JunD-Menin Interaction Regulates c-Jun-mediated AP-1 Transactivation

The gene responsible for multiple endocrine neoplasia type 1, MEN1, encodes the 610-amino acid-protein, menin. Although menin has been reported to bind AP-1 transcription factor JunD and suppress its transcriptional activity, little is known about its molecular mechanisms and physiological role. To...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2004, Vol.51(3), pp.333-342
Hauptverfasser:	IKEO, Yasuto, YUMITA, Wataru, SAKURAI, Akihiro, HASHIZUME, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cercopithecus aethiops COS Cells DNA - metabolism Endocrine tumor Gene Expression Humans MEN1 gene Mice Multiple Endocrine Neoplasia Type 1 Mutation Peptide Fragments - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - pharmacology Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - physiology Recombinant Fusion Proteins Signal transduction Transcription Factor AP-1 - physiology Transcriptional Activation Transfection Tumor suppressor
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