Preparations and spectroscopic studies of organotin complexes of diclofenac

The reactions of the potent and widely used anti-inflammatory drug diclofenac, HL, with diorganotin(IV) oxides were studied. The dimeric tetraorganodistannoxane complexes [Me 2LSnOSnLMe 2] 2, [Bu 2LSnOSnLBu 2] 2, [Ph 2LSnOSnLPh 2] 2 and the dibutyltin complex [Bu 2SnL 2], have been prepared and structurally characterized in the solid state by means of vibrational and 119 Sn Mössbauer spectroscopy. Determination of lattice dynamics by temperature-dependent 119 Sn Mössbauer spectroscopy. From the variable-temperature Mössbauer effect, the Debye temperature was determined. The complexes have been characterized in solution by NMR ( 1 H and 13 C ) spectroscopy. Vibrational, Mössbauer, and NMR data are discussed in terms of the proposed structures.