Effects of tirofiban on haemostatic activation in vitro

Thrombin plays a critical role in normal haemostasis and pathological thrombosis. Heparin has long been a mainstay choice of antithrombotic regimen in cardiac patients, but persistent thrombin generation seems to occur during heparin therapy. Because platelets are integral to primary haemostasis and...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2004-08, Vol.93 (2), p.263-269
Hauptverfasser:	Tanaka, K.A., Katori, N., Szlam, F., Sato, N., Kelly, A.B., Levy, J.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy antithrombin Biological and medical sciences blood Blood Coagulation - drug effects blood, antithrombin blood, platelet inhibitors, tirofiban complications complications, heparin resistance Dose-Response Relationship, Drug Hemostasis - drug effects Heparin - pharmacology heparin resistance Humans In Vitro Techniques Medical sciences Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology platelet inhibitors Thrombin - biosynthesis tirofiban Tyrosine - analogs & derivatives Tyrosine - pharmacology
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