Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (...
Gespeichert in:
| Veröffentlicht in: | Neuroimmunomodulation 2004, Vol.11 (4), p.224-232 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 232 |
|---|---|
| container_issue | 4 |
| container_start_page | 224 |
| container_title | Neuroimmunomodulation |
| container_volume | 11 |
| creator | Auernhammer, Christoph J. Kopp, Florian B. Vlotides, George Dorn, Franziska Isele, Nicola B. Spöttl, Gerald Cengic, Neziha Weber, Matthias M. Senaldi, Giorgio Engelhardt, Dieter |
| description | Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor (CNTF) and novel neurotrophin-1/B-cell stimulating factor-3 (CNTFRα/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes. |
| doi_str_mv | 10.1159/000078440 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66700697</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66700697</sourcerecordid><originalsourceid>FETCH-LOGICAL-c363t-39eb1c217cd8499a40f3b3f4d169c0f5974838ba6050280c2870cce86b88ab6b3</originalsourceid><addsrcrecordid>eNpt0DtLxTAYBuAgivfBWZDgIDhUkyYnTSeR4g28gJe5pLlo9LSpSSqczdnVf-gvMXqOupjlC-TJC98LwAZGexiPyn2UTsEpRXNgGdOcZCjHbD7d08wKivASWAnhMSmCMF8ES3iU07LI-TJ4q1zbCy-ifdHwJg5qAp2B9z0mCFaT6J5sp-GRMVrGAF0HK-ejlS561z_Aw3ib5cnp8TjAj9d3eK3V0CnRyZTi4U2vpTVW2vgdeqkH72zbDp3TnXLSf0VfODWMRXQ-HKyBBSPGQa_P5iq4Oz66rU6z86uTs-rwPJOEkZiRUjdY5riQitOyFBQZ0hBDFWalRGZUFpQT3giGRijnSOa8QFJqzhrORcMasgp2prm9d8-DDrFubZBpB9FpN4SasQIhVhYJ7k6h9C4Er03de9sKP6kxqr-Kr3-LT3ZrFjo0rVZ_ctZ0AptT8CT8vfa_4Of79r-vl2cX36DulSGfEVmTiw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66700697</pqid></control><display><type>article</type><title>Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?</title><source>MEDLINE</source><source>Karger Journals</source><creator>Auernhammer, Christoph J. ; Kopp, Florian B. ; Vlotides, George ; Dorn, Franziska ; Isele, Nicola B. ; Spöttl, Gerald ; Cengic, Neziha ; Weber, Matthias M. ; Senaldi, Giorgio ; Engelhardt, Dieter</creator><creatorcontrib>Auernhammer, Christoph J. ; Kopp, Florian B. ; Vlotides, George ; Dorn, Franziska ; Isele, Nicola B. ; Spöttl, Gerald ; Cengic, Neziha ; Weber, Matthias M. ; Senaldi, Giorgio ; Engelhardt, Dieter</creatorcontrib><description>Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor (CNTF) and novel neurotrophin-1/B-cell stimulating factor-3 (CNTFRα/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes.</description><identifier>ISSN: 1021-7401</identifier><identifier>EISSN: 1423-0216</identifier><identifier>DOI: 10.1159/000078440</identifier><identifier>PMID: 15249728</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adrenocorticotropic Hormone - secretion ; Animals ; Antigens, CD - drug effects ; Antigens, CD - immunology ; Antigens, CD - metabolism ; Cell Line ; Cytokine Receptor gp130 ; Cytokines - immunology ; Cytokines - metabolism ; Cytokines - pharmacology ; DNA-Binding Proteins - drug effects ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Dose-Response Relationship, Drug ; Gene Expression - drug effects ; Gene Expression - immunology ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - immunology ; Leukemia Inhibitory Factor Receptor alpha Subunit ; Ligands ; Membrane Glycoproteins - drug effects ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - metabolism ; Mice ; Neuroimmunomodulation - immunology ; Original Paper ; Phosphorylation - drug effects ; Pituitary Gland, Anterior - cytology ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - immunology ; Pro-Opiomelanocortin - genetics ; Promoter Regions, Genetic - drug effects ; Promoter Regions, Genetic - immunology ; Receptor, Ciliary Neurotrophic Factor - drug effects ; Receptor, Ciliary Neurotrophic Factor - immunology ; Receptor, Ciliary Neurotrophic Factor - metabolism ; Receptors, Cytokine - drug effects ; Receptors, Cytokine - immunology ; Receptors, Cytokine - metabolism ; Receptors, OSM-LIF ; Repressor Proteins - genetics ; RNA, Messenger - drug effects ; RNA, Messenger - metabolism ; STAT1 Transcription Factor ; STAT3 Transcription Factor ; Suppressor of Cytokine Signaling 3 Protein ; Suppressor of Cytokine Signaling Proteins ; Trans-Activators - drug effects ; Trans-Activators - genetics ; Trans-Activators - metabolism ; Transcription Factors - genetics ; Tyrosine - metabolism</subject><ispartof>Neuroimmunomodulation, 2004, Vol.11 (4), p.224-232</ispartof><rights>2004 S. Karger AG, Basel</rights><rights>Copyright 2004 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-39eb1c217cd8499a40f3b3f4d169c0f5974838ba6050280c2870cce86b88ab6b3</citedby><cites>FETCH-LOGICAL-c363t-39eb1c217cd8499a40f3b3f4d169c0f5974838ba6050280c2870cce86b88ab6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15249728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Auernhammer, Christoph J.</creatorcontrib><creatorcontrib>Kopp, Florian B.</creatorcontrib><creatorcontrib>Vlotides, George</creatorcontrib><creatorcontrib>Dorn, Franziska</creatorcontrib><creatorcontrib>Isele, Nicola B.</creatorcontrib><creatorcontrib>Spöttl, Gerald</creatorcontrib><creatorcontrib>Cengic, Neziha</creatorcontrib><creatorcontrib>Weber, Matthias M.</creatorcontrib><creatorcontrib>Senaldi, Giorgio</creatorcontrib><creatorcontrib>Engelhardt, Dieter</creatorcontrib><title>Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?</title><title>Neuroimmunomodulation</title><addtitle>Neuroimmunomodulation</addtitle><description>Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor (CNTF) and novel neurotrophin-1/B-cell stimulating factor-3 (CNTFRα/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes.</description><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Animals</subject><subject>Antigens, CD - drug effects</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - metabolism</subject><subject>Cell Line</subject><subject>Cytokine Receptor gp130</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Cytokines - pharmacology</subject><subject>DNA-Binding Proteins - drug effects</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - immunology</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - immunology</subject><subject>Leukemia Inhibitory Factor Receptor alpha Subunit</subject><subject>Ligands</subject><subject>Membrane Glycoproteins - drug effects</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Mice</subject><subject>Neuroimmunomodulation - immunology</subject><subject>Original Paper</subject><subject>Phosphorylation - drug effects</subject><subject>Pituitary Gland, Anterior - cytology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - immunology</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Promoter Regions, Genetic - drug effects</subject><subject>Promoter Regions, Genetic - immunology</subject><subject>Receptor, Ciliary Neurotrophic Factor - drug effects</subject><subject>Receptor, Ciliary Neurotrophic Factor - immunology</subject><subject>Receptor, Ciliary Neurotrophic Factor - metabolism</subject><subject>Receptors, Cytokine - drug effects</subject><subject>Receptors, Cytokine - immunology</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Receptors, OSM-LIF</subject><subject>Repressor Proteins - genetics</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>STAT1 Transcription Factor</subject><subject>STAT3 Transcription Factor</subject><subject>Suppressor of Cytokine Signaling 3 Protein</subject><subject>Suppressor of Cytokine Signaling Proteins</subject><subject>Trans-Activators - drug effects</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Tyrosine - metabolism</subject><issn>1021-7401</issn><issn>1423-0216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0DtLxTAYBuAgivfBWZDgIDhUkyYnTSeR4g28gJe5pLlo9LSpSSqczdnVf-gvMXqOupjlC-TJC98LwAZGexiPyn2UTsEpRXNgGdOcZCjHbD7d08wKivASWAnhMSmCMF8ES3iU07LI-TJ4q1zbCy-ifdHwJg5qAp2B9z0mCFaT6J5sp-GRMVrGAF0HK-ejlS561z_Aw3ib5cnp8TjAj9d3eK3V0CnRyZTi4U2vpTVW2vgdeqkH72zbDp3TnXLSf0VfODWMRXQ-HKyBBSPGQa_P5iq4Oz66rU6z86uTs-rwPJOEkZiRUjdY5riQitOyFBQZ0hBDFWalRGZUFpQT3giGRijnSOa8QFJqzhrORcMasgp2prm9d8-DDrFubZBpB9FpN4SasQIhVhYJ7k6h9C4Er03de9sKP6kxqr-Kr3-LT3ZrFjo0rVZ_ctZ0AptT8CT8vfa_4Of79r-vl2cX36DulSGfEVmTiw</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Auernhammer, Christoph J.</creator><creator>Kopp, Florian B.</creator><creator>Vlotides, George</creator><creator>Dorn, Franziska</creator><creator>Isele, Nicola B.</creator><creator>Spöttl, Gerald</creator><creator>Cengic, Neziha</creator><creator>Weber, Matthias M.</creator><creator>Senaldi, Giorgio</creator><creator>Engelhardt, Dieter</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?</title><author>Auernhammer, Christoph J. ; Kopp, Florian B. ; Vlotides, George ; Dorn, Franziska ; Isele, Nicola B. ; Spöttl, Gerald ; Cengic, Neziha ; Weber, Matthias M. ; Senaldi, Giorgio ; Engelhardt, Dieter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-39eb1c217cd8499a40f3b3f4d169c0f5974838ba6050280c2870cce86b88ab6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenocorticotropic Hormone - secretion</topic><topic>Animals</topic><topic>Antigens, CD - drug effects</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD - metabolism</topic><topic>Cell Line</topic><topic>Cytokine Receptor gp130</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Cytokines - pharmacology</topic><topic>DNA-Binding Proteins - drug effects</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - immunology</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - immunology</topic><topic>Leukemia Inhibitory Factor Receptor alpha Subunit</topic><topic>Ligands</topic><topic>Membrane Glycoproteins - drug effects</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Mice</topic><topic>Neuroimmunomodulation - immunology</topic><topic>Original Paper</topic><topic>Phosphorylation - drug effects</topic><topic>Pituitary Gland, Anterior - cytology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - immunology</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Promoter Regions, Genetic - drug effects</topic><topic>Promoter Regions, Genetic - immunology</topic><topic>Receptor, Ciliary Neurotrophic Factor - drug effects</topic><topic>Receptor, Ciliary Neurotrophic Factor - immunology</topic><topic>Receptor, Ciliary Neurotrophic Factor - metabolism</topic><topic>Receptors, Cytokine - drug effects</topic><topic>Receptors, Cytokine - immunology</topic><topic>Receptors, Cytokine - metabolism</topic><topic>Receptors, OSM-LIF</topic><topic>Repressor Proteins - genetics</topic><topic>RNA, Messenger - drug effects</topic><topic>RNA, Messenger - metabolism</topic><topic>STAT1 Transcription Factor</topic><topic>STAT3 Transcription Factor</topic><topic>Suppressor of Cytokine Signaling 3 Protein</topic><topic>Suppressor of Cytokine Signaling Proteins</topic><topic>Trans-Activators - drug effects</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Auernhammer, Christoph J.</creatorcontrib><creatorcontrib>Kopp, Florian B.</creatorcontrib><creatorcontrib>Vlotides, George</creatorcontrib><creatorcontrib>Dorn, Franziska</creatorcontrib><creatorcontrib>Isele, Nicola B.</creatorcontrib><creatorcontrib>Spöttl, Gerald</creatorcontrib><creatorcontrib>Cengic, Neziha</creatorcontrib><creatorcontrib>Weber, Matthias M.</creatorcontrib><creatorcontrib>Senaldi, Giorgio</creatorcontrib><creatorcontrib>Engelhardt, Dieter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroimmunomodulation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Auernhammer, Christoph J.</au><au>Kopp, Florian B.</au><au>Vlotides, George</au><au>Dorn, Franziska</au><au>Isele, Nicola B.</au><au>Spöttl, Gerald</au><au>Cengic, Neziha</au><au>Weber, Matthias M.</au><au>Senaldi, Giorgio</au><au>Engelhardt, Dieter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators?</atitle><jtitle>Neuroimmunomodulation</jtitle><addtitle>Neuroimmunomodulation</addtitle><date>2004</date><risdate>2004</risdate><volume>11</volume><issue>4</issue><spage>224</spage><epage>232</epage><pages>224-232</pages><issn>1021-7401</issn><eissn>1423-0216</eissn><abstract>Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM. Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined. Results: Leukemia inhibitory factor (LIF), human oncostatin M (OSM) and cardiotrophin (CT)-1 (LIFR/gp130 ligands), as well as ciliary neurotrophic factor (CNTF) and novel neurotrophin-1/B-cell stimulating factor-3 (CNTFRα/LIFR/gp130 ligands) are potent stimuli of corticotroph cells in vitro. In comparison, interleukin (IL)-6 (IL-6R/gp130 ligand) and IL-11 (IL-11R/gp130 ligand) exhibited only modest direct effects on corticotrophs, while murine OSM (OSMR/gp130 ligand) showed no effect. Conclusion: (i) CNTFR complex ligands are potent stimuli of corticotroph function, comparable to LIFR complex ligands; (ii) IL-6 and IL-11 are relatively weak direct stimuli of corticotroph function; (iii) differential effects of human and murine OSM suggest that LIFR/gp130 (OSMR type I) but not OSMR/gp130 (OSMR type II) are involved in corticotroph signaling. (iv) CT-1 has the hitherto unknown ability to stimulate corticotroph function, and (v) despite redundant immuno-neuroendocrine effects of different gp130 cytokines, corticotroph cells are preferably activated through the LIFR and CNTFR complexes.</abstract><cop>Basel, Switzerland</cop><pmid>15249728</pmid><doi>10.1159/000078440</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1021-7401 |
| ispartof | Neuroimmunomodulation, 2004, Vol.11 (4), p.224-232 |
| issn | 1021-7401 1423-0216 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66700697 |
| source | MEDLINE; Karger Journals |
| subjects | Adrenocorticotropic Hormone - secretion Animals Antigens, CD - drug effects Antigens, CD - immunology Antigens, CD - metabolism Cell Line Cytokine Receptor gp130 Cytokines - immunology Cytokines - metabolism Cytokines - pharmacology DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Gene Expression - drug effects Gene Expression - immunology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - immunology Leukemia Inhibitory Factor Receptor alpha Subunit Ligands Membrane Glycoproteins - drug effects Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Neuroimmunomodulation - immunology Original Paper Phosphorylation - drug effects Pituitary Gland, Anterior - cytology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - immunology Pro-Opiomelanocortin - genetics Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - immunology Receptor, Ciliary Neurotrophic Factor - drug effects Receptor, Ciliary Neurotrophic Factor - immunology Receptor, Ciliary Neurotrophic Factor - metabolism Receptors, Cytokine - drug effects Receptors, Cytokine - immunology Receptors, Cytokine - metabolism Receptors, OSM-LIF Repressor Proteins - genetics RNA, Messenger - drug effects RNA, Messenger - metabolism STAT1 Transcription Factor STAT3 Transcription Factor Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins Trans-Activators - drug effects Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Tyrosine - metabolism |
| title | Comparative Study of gp130 Cytokine Effects on Corticotroph AtT-20 Cells – Redundancy or Specificity of Neuroimmunoendocrine Modulators? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T14%3A46%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20Study%20of%20gp130%20Cytokine%20Effects%20on%20Corticotroph%20AtT-20%20Cells%20%E2%80%93%20Redundancy%20or%20Specificity%20of%20Neuroimmunoendocrine%20Modulators?&rft.jtitle=Neuroimmunomodulation&rft.au=Auernhammer,%20Christoph%20J.&rft.date=2004&rft.volume=11&rft.issue=4&rft.spage=224&rft.epage=232&rft.pages=224-232&rft.issn=1021-7401&rft.eissn=1423-0216&rft_id=info:doi/10.1159/000078440&rft_dat=%3Cproquest_cross%3E66700697%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=66700697&rft_id=info:pmid/15249728&rfr_iscdi=true |