Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats
We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilater...
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| Veröffentlicht in: | Neuroscience letters 2004-07, Vol.365 (2), p.128-131 |
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| container_title | Neuroscience letters |
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| creator | Fukumori, Ryuji Nishigori, Yusuke Goshima, Yoshio Kubo, Takao |
| description | We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilateral lesions of the medial amygdaloid nucleus attenuated the development of hypertension in SHR. Body weight gain was not different between lesioned and sham-lesioned SHR throughout the experimental periods. These data suggest that neurons in the medial amygdaloid nucleus may be involved in the development of hypertension in SHR. |
| doi_str_mv | 10.1016/j.neulet.2004.04.066 |
| format | Article |
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In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilateral lesions of the medial amygdaloid nucleus attenuated the development of hypertension in SHR. Body weight gain was not different between lesioned and sham-lesioned SHR throughout the experimental periods. These data suggest that neurons in the medial amygdaloid nucleus may be involved in the development of hypertension in SHR.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.04.066</identifier><identifier>PMID: 15245793</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Amygdala - drug effects ; Amygdala - physiopathology ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Body weight gain ; Cardiology. Vascular system ; Development of hypertension ; Experimental diseases ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypertension - physiopathology ; Ibotenic Acid ; Male ; Medial amygdala ; Medical sciences ; Rats ; Rats, Inbred SHR ; Spontaneous hypertension ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-07, Vol.365 (2), p.128-131</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-4f4da53f8ede98fb87f4ccc4c4c847f00fae258d251219996dbc7158753f4ff43</citedby><cites>FETCH-LOGICAL-c388t-4f4da53f8ede98fb87f4ccc4c4c847f00fae258d251219996dbc7158753f4ff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439400400521X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15925748$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15245793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukumori, Ryuji</creatorcontrib><creatorcontrib>Nishigori, Yusuke</creatorcontrib><creatorcontrib>Goshima, Yoshio</creatorcontrib><creatorcontrib>Kubo, Takao</creatorcontrib><title>Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. In this study, neuronal perikarya in the medial amygdaloid nucleus of 4-week-old spontaneously hypertensive rats (SHR) were selectively destroyed with ibotenic acid. Bilateral lesions of the medial amygdaloid nucleus attenuated the development of hypertension in SHR. Body weight gain was not different between lesioned and sham-lesioned SHR throughout the experimental periods. These data suggest that neurons in the medial amygdaloid nucleus may be involved in the development of hypertension in SHR.</description><subject>Amygdala - drug effects</subject><subject>Amygdala - physiopathology</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Body weight gain</subject><subject>Cardiology. Vascular system</subject><subject>Development of hypertension</subject><subject>Experimental diseases</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Ibotenic Acid</subject><subject>Male</subject><subject>Medial amygdala</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Spontaneous hypertension</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGP1CAYhonRuLOr_8CYXvTWEVqgcDExE3VNNvGiZ8LQD5cJhQp0kvn3UjuJezJ8CQee982XB4TeELwnmPAPp32AxUPZdxjT_TqcP0M7IoauHeTQPUc73GPa9pLiG3Sb8wljzAijL9ENYR1lg-x3KB9iKMkdl-JiaKJtyiM0E4xO-0ZPl1-j9tGNTViMhyU3Jf4FRjiDj_MEoayZx8sMqUDIa4cLTZ5rqQ4Ql-wvT17P0CRd8iv0wmqf4fX1vkM_v3z-cbhvH75__Xb49NCaXojSUktHzXorYAQp7FEMlhpjaD2CDhZjq6FjYuwY6YiUko9HMxAmhpqh1tL-Dr3feucUfy-Qi5pcNuD9tprinEtJGKkg3UCTYs4JrJqTm3S6KILVKlud1CZbrbLVOpzX2Ntr_3Ksyv6FrnYr8O4K6Gy0t0kH4_ITTnZsoKJyHzcOqo2zg6SycRBM_YYEpqgxuv9v8gfjWKL2</recordid><startdate>20040722</startdate><enddate>20040722</enddate><creator>Fukumori, Ryuji</creator><creator>Nishigori, Yusuke</creator><creator>Goshima, Yoshio</creator><creator>Kubo, Takao</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040722</creationdate><title>Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats</title><author>Fukumori, Ryuji ; Nishigori, Yusuke ; Goshima, Yoshio ; Kubo, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-4f4da53f8ede98fb87f4ccc4c4c847f00fae258d251219996dbc7158753f4ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amygdala - drug effects</topic><topic>Amygdala - physiopathology</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Body weight gain</topic><topic>Cardiology. Vascular system</topic><topic>Development of hypertension</topic><topic>Experimental diseases</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Ibotenic Acid</topic><topic>Male</topic><topic>Medial amygdala</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Spontaneous hypertension</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukumori, Ryuji</creatorcontrib><creatorcontrib>Nishigori, Yusuke</creatorcontrib><creatorcontrib>Goshima, Yoshio</creatorcontrib><creatorcontrib>Kubo, Takao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukumori, Ryuji</au><au>Nishigori, Yusuke</au><au>Goshima, Yoshio</au><au>Kubo, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2004-07-22</date><risdate>2004</risdate><volume>365</volume><issue>2</issue><spage>128</spage><epage>131</epage><pages>128-131</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>We previously demonstrated involvement of the medial amygdaloid nucleus in restraint stress-induced pressor responses in rats. 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| ispartof | Neuroscience letters, 2004-07, Vol.365 (2), p.128-131 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amygdala - drug effects Amygdala - physiopathology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Body weight gain Cardiology. Vascular system Development of hypertension Experimental diseases Fundamental and applied biological sciences. Psychology Humans Hypertension - physiopathology Ibotenic Acid Male Medial amygdala Medical sciences Rats Rats, Inbred SHR Spontaneous hypertension Vertebrates: nervous system and sense organs |
| title | Contribution of the medial amygdaloid nucleus to the development of hypertension in spontaneously hypertensive rats |
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