Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge

Mucosal surfaces are important for the induction of immunity against influenza virus. In a murine intranasal immunization model, we demonstrated that the attenuated Shigella flexneri Δasd strain 15D, carrying a DNA construct encoding the influenza virus hemagglutinin (HA), induces protective immunit...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2004-08, Vol.325 (2), p.192-199
Hauptverfasser:	Vecino, William H, Quanquin, Natalie M, Martinez-Sobrido, Luis, Fernandez-Sesma, Ana, Garcı́a-Sastre, Adolfo, Jacobs, William R, Fennelly, Glenn J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Attenuated shigella Bacterial vector Base Sequence DNA vaccines Female Genetic Vectors Hemagglutinin Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology IFN-γ Immunity, Mucosal Immunization Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza virus Mice Mice, Inbred BALB C Mucosal immunity Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Pandemic Plasmids - genetics Shigella flexneri Shigella flexneri - genetics Shigella flexneri - immunology T cell Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, DNA - administration & dosage Vaccines, DNA - genetics
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