Impact on estrogen receptor binding and target tissue uptake of [18F]fluorine substitution at the 16alpha-position of fulvestrant (faslodex; ICI 182,780)

Fulvestrant (Faslodex; ICI 182,780) is a pure estrogen receptor (ER) antagonist recently approved for the treatment of hormone-sensitive breast cancer in post-menopausal women with disease progression following antiestrogen therapy. Fulvestrant strongly binds to the ER and its mode of action consist...

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Veröffentlicht in:	Nuclear medicine and biology 2004-08, Vol.31 (6), p.691-698
Hauptverfasser:	Seimbille, Yann, Bénard, François, Rousseau, Jacques, Pepin, Emilie, Aliaga, Antonio, Tessier, Guillaume, van Lier, Johan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Estradiol - analogs & derivatives Estradiol - chemistry Estradiol - metabolism Estrogen Receptor Modulators - chemistry Estrogen Receptor Modulators - metabolism Female Fluorine Radioisotopes Indicators and Reagents Isotope Labeling Mammary Neoplasms, Experimental - diagnostic imaging Mammary Neoplasms, Experimental - drug therapy Positron-Emission Tomography Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - metabolism Rats Rats, Sprague-Dawley Receptors, Estrogen - metabolism Sulfates - chemistry Tissue Distribution Uterus - diagnostic imaging Uterus - metabolism
Online-Zugang:	Volltext
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