Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation
The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain...
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| Veröffentlicht in: | Brain research 2004-08, Vol.1016 (2), p.255-262 |
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| creator | Sutoo, Den'etsu Akiyama, Kayo |
| description | The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. Music might regulate and/or affect various brain functions through dopaminergic neurotransmission, and might therefore be effective for rectification of symptoms in various diseases that involve DA dysfunction. |
| doi_str_mv | 10.1016/j.brainres.2004.05.018 |
| format | Article |
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Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. Music might regulate and/or affect various brain functions through dopaminergic neurotransmission, and might therefore be effective for rectification of symptoms in various diseases that involve DA dysfunction.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2004.05.018</identifier><identifier>PMID: 15246862</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>alpha-Methyltyrosine - pharmacology ; Animals ; Anticoagulants ; Benzazepines - pharmacology ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Brain - anatomy & histology ; Brain - drug effects ; Brain - metabolism ; Calcium - blood ; Calcium/calmodulin-dependent dopamine synthesis ; Cell Count - methods ; Dopamine - metabolism ; Dopamine Antagonists - pharmacology ; Dopamine dysfunction ; Edetic Acid - pharmacology ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry - methods ; Male ; Models, Biological ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Music ; Music - psychology ; Neostriatum ; Rats ; Rats, Inbred SHR ; Salicylamides - pharmacology ; Spontaneously hypertensive rat ; Sulfonamides - pharmacology ; Systolic blood pressure ; Time Factors ; Vasodilator Agents - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 2004-08, Vol.1016 (2), p.255-262</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-d40bcb0b26a334f7e8a3b8ee767bf8700107f5b2b74ddc3114e2fb412e326cd33</citedby><cites>FETCH-LOGICAL-c425t-d40bcb0b26a334f7e8a3b8ee767bf8700107f5b2b74ddc3114e2fb412e326cd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000689930400736X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15954287$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15246862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sutoo, Den'etsu</creatorcontrib><creatorcontrib>Akiyama, Kayo</creatorcontrib><title>Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. Music might regulate and/or affect various brain functions through dopaminergic neurotransmission, and might therefore be effective for rectification of symptoms in various diseases that involve DA dysfunction.</description><subject>alpha-Methyltyrosine - pharmacology</subject><subject>Animals</subject><subject>Anticoagulants</subject><subject>Benzazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Brain - anatomy & histology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Calcium - blood</subject><subject>Calcium/calmodulin-dependent dopamine synthesis</subject><subject>Cell Count - methods</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dopamine dysfunction</subject><subject>Edetic Acid - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Music</subject><subject>Music - psychology</subject><subject>Neostriatum</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Salicylamides - pharmacology</subject><subject>Spontaneously hypertensive rat</subject><subject>Sulfonamides - pharmacology</subject><subject>Systolic blood pressure</subject><subject>Time Factors</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERbeFv1D5ArcEf8VOOIEqoEiteilnyx_j4lUSL3ayUv893u4iuPVkz_h5xzPzInRFSUsJlR-3rc0mzhlKywgRLelaQvtXaEN7xRrJBHmNNoQQ2fTDwM_RRSnbGnI-kDfonHZMyF6yDdrfrSU6HKddTnso2KedmeIM-bFmZ1hzWrKZyxRLiWn-hD1MaS41t9QQW1PA43pZfgGGEMAtOAU8Pdc8vI8pebyrXZY1A87wuI7PyrfoLJixwLvTeYl-fvv6cH3T3N5__3H95bZxgnVL4wWxzhLLpOFcBAW94bYHUFLZ0CtCKFGhs8wq4b3jlApgwQrKgDPpPOeX6MOxbh3v9wpl0XUSB-NoZkhr0VLKQdKBvAhS1TOmxFBBeQRdTqVkCHqX42Tyk6ZEH6zRW_3XGn2wRpNOV2uq8Or0w2on8P9kJy8q8P4EmOLMGOreXSz_cUMnWK8q9_nIQV3cPkLWxUWYHfiYqwHap_hSL38AxW-zPg</recordid><startdate>20040806</startdate><enddate>20040806</enddate><creator>Sutoo, Den'etsu</creator><creator>Akiyama, Kayo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040806</creationdate><title>Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation</title><author>Sutoo, Den'etsu ; Akiyama, Kayo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-d40bcb0b26a334f7e8a3b8ee767bf8700107f5b2b74ddc3114e2fb412e326cd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>alpha-Methyltyrosine - pharmacology</topic><topic>Animals</topic><topic>Anticoagulants</topic><topic>Benzazepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Brain - anatomy & histology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Calcium - blood</topic><topic>Calcium/calmodulin-dependent dopamine synthesis</topic><topic>Cell Count - methods</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine dysfunction</topic><topic>Edetic Acid - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Music</topic><topic>Music - psychology</topic><topic>Neostriatum</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Salicylamides - pharmacology</topic><topic>Spontaneously hypertensive rat</topic><topic>Sulfonamides - pharmacology</topic><topic>Systolic blood pressure</topic><topic>Time Factors</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sutoo, Den'etsu</creatorcontrib><creatorcontrib>Akiyama, Kayo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sutoo, Den'etsu</au><au>Akiyama, Kayo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2004-08-06</date><risdate>2004</risdate><volume>1016</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The mechanism by which music modifies brain function is not clear. Clinical findings indicate that music reduces blood pressure in various patients. We investigated the effect of music on blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that calcium increases brain dopamine (DA) synthesis through a calmodulin (CaM)-dependent system. Increased DA levels reduce blood pressure in SHR. In this study, we examined the effects of music on this pathway. Systolic blood pressure in SHR was reduced by exposure to Mozart's music (K.205), and the effect vanished when this pathway was inhibited. Exposure to music also significantly increased serum calcium levels and neostriatal DA levels. These results suggest that music leads to increased calcium/CaM-dependent DA synthesis in the brain, thus causing a reduction in blood pressure. 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| subjects | alpha-Methyltyrosine - pharmacology Animals Anticoagulants Benzazepines - pharmacology Biological and medical sciences Blood Pressure - drug effects Blood Pressure - physiology Brain - anatomy & histology Brain - drug effects Brain - metabolism Calcium - blood Calcium/calmodulin-dependent dopamine synthesis Cell Count - methods Dopamine - metabolism Dopamine Antagonists - pharmacology Dopamine dysfunction Edetic Acid - pharmacology Fundamental and applied biological sciences. Psychology Immunohistochemistry - methods Male Models, Biological Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Music Music - psychology Neostriatum Rats Rats, Inbred SHR Salicylamides - pharmacology Spontaneously hypertensive rat Sulfonamides - pharmacology Systolic blood pressure Time Factors Vasodilator Agents - pharmacology Vertebrates: nervous system and sense organs |
| title | Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation |
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