Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds

Chiral derivatives of several substituted halopyridyl and thiazolyl PETT compounds were synthesized as non-nucleoside inhibitors of the reverse transcriptase (RT) enzyme (NNRTI) of the human immunodeficiency virus (HIV-1). Molecular modeling studies indicated that because of the asymmetric geometry...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2004-08, Vol.12 (15), p.4275-4284
Hauptverfasser:	Venkatachalam, T.K, Mao, C, Uckun, Fatih.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Evaluation, Preclinical HIV-1 - drug effects Humans Medical sciences Models, Molecular Molecular Conformation Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - chemical synthesis Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology Stereoisomerism Structure-Activity Relationship Thiourea - chemical synthesis Thiourea - chemistry Thiourea - pharmacology Virus Replication - drug effects
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