Neurodegenerative disease and iron storage in the brain

Iron is very important for normal regulation of various metabolic pathways. Neurons store iron in the form of ferrous ion or neuromelanin. In specific disorders the axonal transport of iron is impaired, leading to iron deposition which in the presence of reactive oxygen species results in neurodegen...

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Veröffentlicht in:	Current opinion in neurology 2004-08, Vol.17 (4), p.437-442
Hauptverfasser:	Thomas, Madhavi, Jankovic, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - pathology Brain - physiopathology Disease Models, Animal Ferritins - deficiency Ferritins - genetics Humans Iron - metabolism Iron Metabolism Disorders - genetics Iron Metabolism Disorders - metabolism Iron Metabolism Disorders - physiopathology Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - physiopathology Neurons - metabolism Neurons - pathology Phosphotransferases (Alcohol Group Acceptor) - deficiency Phosphotransferases (Alcohol Group Acceptor) - genetics
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