Examination of edge effects with different storage conditions of preplated dimethyl sulfoxide nanospots in ChemLib 1,536- and 3,456-well assay-ready plates

For ultra-high-throughput screening, 10-30 nl of compound dissolved in 75% dimethyl sulfoxide (DMSO)/25% water (vol/vol) is spotted into 1,536- and 3,456-well ChemLib plates (Aurora Biotechnologies, Carlsbad, CA) and stored appropriately for a short time before screening. Although this practice elim...

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Veröffentlicht in:	Assay and drug development technologies 2008-12, Vol.6 (6), p.811-818
Hauptverfasser:	Turner, Benjamin A, Evans, Brad P, Pearson, Tania T, Braden, Timothy K, Wise, Scott C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Assay Chemical properties Cytochrome P-450 CYP3A - metabolism Dimethyl sulfoxide Dimethyl Sulfoxide - chemistry Dimethyl Sulfoxide - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - trends Drugs Fluorescent Dyes - chemistry Fluorometry - instrumentation Fluorometry - methods Humidity Indicators and Reagents - chemistry Methods Nanospheres - analysis Nanospheres - chemistry Preservation, Biological - methods Refrigeration Robotics Solvents - chemistry Temperature Time Factors Volatilization
Online-Zugang:	Volltext
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