Palladium-Catalyzed Asymmetric Decarboxylative Lactamization of γ-Methylidene-δ-valerolactones with Isocyanates: Conversion of Racemic Lactones to Enantioenriched Lactams

A palladium-catalyzed asymmetric decarboxylative reaction of racemic γ-methylidene-δ-valerolactones with aryl isocyanates has been developed to give enantioenriched 3,3-disubstituted 2-piperidones. High enantioselectivity has been achieved by tuning the ester group on substrate and the substituents...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-12, Vol.130 (48), p.16174-16175
Hauptverfasser:	Shintani, Ryo, Park, Soyoung, Shirozu, Fumitaka, Murakami, Masataka, Hayashi, Tamio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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