Nucleolin Is a Second Component of the CD154 mRNA Stability Complex That Regulates mRNA Turnover in Activated T Cells

CD154 (CD40L) mRNA turnover is regulated in part at the posttranscriptional level by a protein complex (termed Complex I) that binds to a highly CU-rich region of the 3'UTR. Polypyrimidine tract-binding protein (PTB) has previously been identified as a major RNA-binding protein in Complex I. No...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-07, Vol.173 (2), p.976-985
Hauptverfasser:	Singh, Karnail, Laughlin, Jennifer, Kosinski, Penelope A, Covey, Lori R
Format:	Artikel
Sprache:	eng
Schlagworte:	CD40 Ligand - biosynthesis CD40 Ligand - genetics Humans Macromolecular Substances Nucleolin Phosphoproteins - metabolism Polypyrimidine Tract-Binding Protein - metabolism RNA, Messenger - metabolism RNA-Binding Proteins - metabolism T-Lymphocytes - metabolism
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