A surgical rat model of human roux-en- Y gastric bypass
Obesity affects 30% of the United States population and its detrimental effects are obesity-related metabolic diseases. For patients refractory to conventional weight loss therapy, gastric bypass surgery is one of the proven methods for inducing a sustained weight loss and reversing the metabolic se...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2004-07, Vol.8 (5), p.621-630 |
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| container_title | Journal of gastrointestinal surgery |
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| creator | Meguid, Michael M Ramos, Eduardo J.B Suzuki, Susumu Xu, Yuan George, Zachariah M Das, Undurti N Hughes, Karen Quinn, Robert Chen, Chung Marx, William Cunningham, Paul R.G |
| description | Obesity affects 30% of the United States population and its detrimental effects are obesity-related metabolic diseases. For patients refractory to conventional weight loss therapy, gastric bypass surgery is one of the proven methods for inducing a sustained weight loss and reversing the metabolic sequelae of obesity. To understand the mechanisms of weight loss and the amelioration of related metabolic comorbid conditions, a reproducible animal model is needed. We report our developmental experience with rat models of sequential Roux-en-
Y gastric bypass after reproducing the diet-induced obesity that characterizes the hallmarks of human obesity. Four experiments were performed to induce weight reduction through successive modifications: In Experiment 1 a 20% stapled gastric pouch with a 16 cm biliary-pancreatic limb and a 10 cm alimentary limb accomplished sufficient weight loss within 10 days to ameliorate metabolic changes associated with obesity, but the occurrence of gastrogastric fistulas prevented sustained weight loss; in Experiment 2 the model was improved by dividing the stomach to avoid gastrogastric fistula, but again sustained weight loss was not achieved; in Experiment 3 the biliary-pancreatic limb was lengthened from 16 to 30 cm, reducing the common channel to approximately 18 cm. Sustained weight loss was achieved for 28 days. In Experiment 4 the model in Experiment 3 was modified by dividing the stomach between two rows of staples. Sustained weight loss was observed for 67 days. We developed a reproducible rat model of Roux-en-
Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss. |
| doi_str_mv | 10.1016/j.gassur.2004.02.003 |
| format | Article |
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Y gastric bypass after reproducing the diet-induced obesity that characterizes the hallmarks of human obesity. Four experiments were performed to induce weight reduction through successive modifications: In Experiment 1 a 20% stapled gastric pouch with a 16 cm biliary-pancreatic limb and a 10 cm alimentary limb accomplished sufficient weight loss within 10 days to ameliorate metabolic changes associated with obesity, but the occurrence of gastrogastric fistulas prevented sustained weight loss; in Experiment 2 the model was improved by dividing the stomach to avoid gastrogastric fistula, but again sustained weight loss was not achieved; in Experiment 3 the biliary-pancreatic limb was lengthened from 16 to 30 cm, reducing the common channel to approximately 18 cm. Sustained weight loss was achieved for 28 days. In Experiment 4 the model in Experiment 3 was modified by dividing the stomach between two rows of staples. Sustained weight loss was observed for 67 days. We developed a reproducible rat model of Roux-en-
Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1016/j.gassur.2004.02.003</identifier><identifier>PMID: 15240001</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anastomosis, Roux-en-Y - methods ; Animals ; Diet ; Diet - adverse effects ; diet-induced obese rat ; Experiments ; Gastric Bypass - methods ; Gastrointestinal surgery ; Male ; Metabolic disorders ; Models, Animal ; Obesity ; Obesity - etiology ; Obesity - surgery ; rat model ; Rats ; RYGB ; Weight control ; Weight Loss</subject><ispartof>Journal of gastrointestinal surgery, 2004-07, Vol.8 (5), p.621-630</ispartof><rights>2004 The Society for Surgery of the Alimentary Tract</rights><rights>The Society for Surgery of the Alimentary Tract, Inc. 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15240001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meguid, Michael M</creatorcontrib><creatorcontrib>Ramos, Eduardo J.B</creatorcontrib><creatorcontrib>Suzuki, Susumu</creatorcontrib><creatorcontrib>Xu, Yuan</creatorcontrib><creatorcontrib>George, Zachariah M</creatorcontrib><creatorcontrib>Das, Undurti N</creatorcontrib><creatorcontrib>Hughes, Karen</creatorcontrib><creatorcontrib>Quinn, Robert</creatorcontrib><creatorcontrib>Chen, Chung</creatorcontrib><creatorcontrib>Marx, William</creatorcontrib><creatorcontrib>Cunningham, Paul R.G</creatorcontrib><title>A surgical rat model of human roux-en- Y gastric bypass</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><description>Obesity affects 30% of the United States population and its detrimental effects are obesity-related metabolic diseases. For patients refractory to conventional weight loss therapy, gastric bypass surgery is one of the proven methods for inducing a sustained weight loss and reversing the metabolic sequelae of obesity. To understand the mechanisms of weight loss and the amelioration of related metabolic comorbid conditions, a reproducible animal model is needed. We report our developmental experience with rat models of sequential Roux-en-
Y gastric bypass after reproducing the diet-induced obesity that characterizes the hallmarks of human obesity. Four experiments were performed to induce weight reduction through successive modifications: In Experiment 1 a 20% stapled gastric pouch with a 16 cm biliary-pancreatic limb and a 10 cm alimentary limb accomplished sufficient weight loss within 10 days to ameliorate metabolic changes associated with obesity, but the occurrence of gastrogastric fistulas prevented sustained weight loss; in Experiment 2 the model was improved by dividing the stomach to avoid gastrogastric fistula, but again sustained weight loss was not achieved; in Experiment 3 the biliary-pancreatic limb was lengthened from 16 to 30 cm, reducing the common channel to approximately 18 cm. Sustained weight loss was achieved for 28 days. In Experiment 4 the model in Experiment 3 was modified by dividing the stomach between two rows of staples. Sustained weight loss was observed for 67 days. We developed a reproducible rat model of Roux-en-
Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss.</description><subject>Anastomosis, Roux-en-Y - methods</subject><subject>Animals</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>diet-induced obese rat</subject><subject>Experiments</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal surgery</subject><subject>Male</subject><subject>Metabolic disorders</subject><subject>Models, Animal</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - surgery</subject><subject>rat model</subject><subject>Rats</subject><subject>RYGB</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkctKxDAUhoMoXkbfQCQguGs9J2nTdiOIeIMBNwq6Ckl6ZuzQy5i04ry9kdGNq3Ph4z-Xn7FThBQB1eUqXZoQJp8KgCwFkQLIHXaIZSGTTAm1G3OoMBF5_nrAjkJYAWABWO6zA8xFBrE8ZMU1jxrLxpmWezPybqip5cOCv0-d6bkfpq-E-oS_8Tht9I3jdrOOc4_Z3sK0gU5-44y93N0-3zwk86f7x5vreUKigjERmSRZ5U4sqM4B6txWC1nVhSQSSkCZW0IEW5SZLQxJiwYdWFdW0qnYsnLGLra6az98TBRG3TXBUduanoYpaKVUWeVCRPD8H7gaJt_H3TQiClkiCBmps19qsh3Veu2bzviN_ntIBK62AMWjPhvyOriGekd148mNuh4ajaB_HNArvXVA_zigQejogPwGPD13JQ</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Meguid, Michael M</creator><creator>Ramos, Eduardo J.B</creator><creator>Suzuki, Susumu</creator><creator>Xu, Yuan</creator><creator>George, Zachariah M</creator><creator>Das, Undurti N</creator><creator>Hughes, Karen</creator><creator>Quinn, Robert</creator><creator>Chen, Chung</creator><creator>Marx, William</creator><creator>Cunningham, Paul R.G</creator><general>Elsevier Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>A surgical rat model of human roux-en- Y gastric bypass</title><author>Meguid, Michael M ; 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For patients refractory to conventional weight loss therapy, gastric bypass surgery is one of the proven methods for inducing a sustained weight loss and reversing the metabolic sequelae of obesity. To understand the mechanisms of weight loss and the amelioration of related metabolic comorbid conditions, a reproducible animal model is needed. We report our developmental experience with rat models of sequential Roux-en-
Y gastric bypass after reproducing the diet-induced obesity that characterizes the hallmarks of human obesity. Four experiments were performed to induce weight reduction through successive modifications: In Experiment 1 a 20% stapled gastric pouch with a 16 cm biliary-pancreatic limb and a 10 cm alimentary limb accomplished sufficient weight loss within 10 days to ameliorate metabolic changes associated with obesity, but the occurrence of gastrogastric fistulas prevented sustained weight loss; in Experiment 2 the model was improved by dividing the stomach to avoid gastrogastric fistula, but again sustained weight loss was not achieved; in Experiment 3 the biliary-pancreatic limb was lengthened from 16 to 30 cm, reducing the common channel to approximately 18 cm. Sustained weight loss was achieved for 28 days. In Experiment 4 the model in Experiment 3 was modified by dividing the stomach between two rows of staples. Sustained weight loss was observed for 67 days. We developed a reproducible rat model of Roux-en-
Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15240001</pmid><doi>10.1016/j.gassur.2004.02.003</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2004-07, Vol.8 (5), p.621-630 |
| issn | 1091-255X 1873-4626 |
| language | eng |
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| subjects | Anastomosis, Roux-en-Y - methods Animals Diet Diet - adverse effects diet-induced obese rat Experiments Gastric Bypass - methods Gastrointestinal surgery Male Metabolic disorders Models, Animal Obesity Obesity - etiology Obesity - surgery rat model Rats RYGB Weight control Weight Loss |
| title | A surgical rat model of human roux-en- Y gastric bypass |
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