The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor

Topors was identified recently as a human protein that binds to topoisomerase I and p53. Topors contains a highly conserved RING domain and localizes in promyelocytic leukemia nuclear bodies. Relatively little is known regarding topors expression patterns or function. We now demonstrate that topors...

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Veröffentlicht in:	Oncogene 2004-07, Vol.23 (31), p.5293-5300
Hauptverfasser:	Saleem, Ahamed, Dutta, Jayeeta, Malegaonkar, Diptee, Rasheed, Farheena, Rasheed, Zeshaan, Rajendra, Rajeev, Marshall, Henderson, Luo, Minje, Li, Honghua, Rubin, Eric H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - metabolism Apoptosis Biological and medical sciences Carrier Proteins - biosynthesis Cell Biology Cell Cycle Cell Division Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 9 Colon - metabolism Colon cancer Colonic Neoplasms - metabolism Colorectal cancer CpG Islands Dentistry DNA Methylation DNA topoisomerase DNA-Binding Proteins - biosynthesis Flow Cytometry Fundamental and applied biological sciences. Psychology G1 Phase Gene mapping Genes, Tumor Suppressor Green Fluorescent Proteins HeLa Cells Heterozygosity Human Genetics Humans Internal Medicine Leukemia Loss of Heterozygosity Luminescent Proteins - metabolism Medical schools Medicine Medicine & Public Health Molecular and cellular biology mRNA Neoplasm Proteins Nuclear Proteins - biosynthesis Oncology original-paper p53 Protein Promyeloid leukemia Protein Structure, Tertiary Proteins Resting Phase, Cell Cycle Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Thymidine - metabolism Time Factors Tissue Distribution Transcription Factors - biosynthesis Tumor cell lines Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism Tumors U937 Cells Ubiquitin-Protein Ligases - metabolism
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