Estrogen to Antiestrogen with a Single Methylene Group Resulting in an Unusual Steroidal Selective Estrogen Receptor Modulator

Selective estrogen receptor (ER) modulators (SERMs) are important therapeutic agents for breast cancer prevention and treatment. We have synthesized two analogs, E11–2,1 [methyl-(3,17β-dihydroxyestra-1,3,5(10)-triene-11β-yl)acetate] and E11–2,2 [ethyl-(3,17β-dihydroxyestra-1,3,5(10)-triene-11β-yl)ac...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2004-07, Vol.89 (7), p.3527-3535
Hauptverfasser:	Zhang, Jing-xin, Labaree, David C., Mor, Gil, Hochberg, Richard B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight - drug effects Bone and Bones - drug effects Bone and Bones - pathology Cell Line, Tumor Cholesterol - blood Dose-Response Relationship, Drug Endocrinopathies Estradiol - analogs & derivatives Estradiol - chemistry Estradiol - pharmacology Estrogen Antagonists - chemistry Estrogen Antagonists - pharmacology Estrogen Receptor alpha Estrogen Receptor beta Estrogens - agonists Female Fundamental and applied biological sciences. Psychology Humans Hydrocarbons Medical sciences Methane - analogs & derivatives Organ Size - drug effects Rats Rats, Sprague-Dawley Receptors, Estrogen - drug effects Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - chemistry Selective Estrogen Receptor Modulators - pharmacology Transfection Uterus - drug effects Uterus - pathology Vertebrates: endocrinology
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