Orexins (Hypocretins) and Adrenal Function
Abstract The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the...
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| Veröffentlicht in: | Hormone and metabolic research 2004-06, Vol.36 (6), p.370-375 |
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| container_title | Hormone and metabolic research |
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| creator | Jöhren, O. Brüggemann, N. Dominiak, P. |
| description | Abstract
The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system. In rat and human adrenal glands, both OX
1
and OX
2
receptor subtypes have been described with a predominant expression of OX
2
receptors in the adrenal cortex. In male rats, adrenocortical OX
2
receptors are much higher expressed than in female rats. Various experimental data demonstrate a stimulatory effect of orexins on the secretion of adrenocortical steroids, mainly on glucocorticoids. Some results also suggest the regulation of catecholamine synthesis and release by orexins. Whether the gender-dependent expression of adrenocortical OX
2
receptors has functional correlates awaits future clarification. As plasma orexin appears to rise during hunger and hypoglycemia, orexins may link adrenal functions with energy homeostasis. |
| doi_str_mv | 10.1055/s-2004-814569 |
| format | Article |
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The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system. In rat and human adrenal glands, both OX
1
and OX
2
receptor subtypes have been described with a predominant expression of OX
2
receptors in the adrenal cortex. In male rats, adrenocortical OX
2
receptors are much higher expressed than in female rats. Various experimental data demonstrate a stimulatory effect of orexins on the secretion of adrenocortical steroids, mainly on glucocorticoids. Some results also suggest the regulation of catecholamine synthesis and release by orexins. Whether the gender-dependent expression of adrenocortical OX
2
receptors has functional correlates awaits future clarification. As plasma orexin appears to rise during hunger and hypoglycemia, orexins may link adrenal functions with energy homeostasis.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2004-814569</identifier><identifier>PMID: 15241726</identifier><language>eng</language><publisher>Germany</publisher><subject>Adrenal Glands - physiology ; Catecholamines - biosynthesis ; Feeding Behavior - physiology ; Gene Expression Regulation - physiology ; Glucocorticoids - secretion ; Humans ; Hunger - physiology ; Hypoglycemia - physiopathology ; Intracellular Signaling Peptides and Proteins - physiology ; Neuropeptides - physiology ; Neurosecretory Systems - physiology ; Orexin Receptors ; Orexins ; Receptors, G-Protein-Coupled ; Receptors, Neuropeptide - metabolism ; Review ; Sex Factors ; Sleep - physiology</subject><ispartof>Hormone and metabolic research, 2004-06, Vol.36 (6), p.370-375</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-fe093c51141f0ceff3dec8b683f20d57827fe1a0a1efed223935fb6295149def3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-814569.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2004-814569$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15241726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jöhren, O.</creatorcontrib><creatorcontrib>Brüggemann, N.</creatorcontrib><creatorcontrib>Dominiak, P.</creatorcontrib><title>Orexins (Hypocretins) and Adrenal Function</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Abstract
The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system. In rat and human adrenal glands, both OX
1
and OX
2
receptor subtypes have been described with a predominant expression of OX
2
receptors in the adrenal cortex. In male rats, adrenocortical OX
2
receptors are much higher expressed than in female rats. Various experimental data demonstrate a stimulatory effect of orexins on the secretion of adrenocortical steroids, mainly on glucocorticoids. Some results also suggest the regulation of catecholamine synthesis and release by orexins. Whether the gender-dependent expression of adrenocortical OX
2
receptors has functional correlates awaits future clarification. As plasma orexin appears to rise during hunger and hypoglycemia, orexins may link adrenal functions with energy homeostasis.</description><subject>Adrenal Glands - physiology</subject><subject>Catecholamines - biosynthesis</subject><subject>Feeding Behavior - physiology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Glucocorticoids - secretion</subject><subject>Humans</subject><subject>Hunger - physiology</subject><subject>Hypoglycemia - physiopathology</subject><subject>Intracellular Signaling Peptides and Proteins - physiology</subject><subject>Neuropeptides - physiology</subject><subject>Neurosecretory Systems - physiology</subject><subject>Orexin Receptors</subject><subject>Orexins</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Receptors, Neuropeptide - metabolism</subject><subject>Review</subject><subject>Sex Factors</subject><subject>Sleep - physiology</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEURoMotlaXbmVWomI075ksS1ErFLrRdZgmNzhlHjWZAfvvTZmCK1eXDw6Hy0HompInSqR8jpgRInBBhVT6BE2p4BoLVqhTNCWEFlgSwSfoIsZtmkJTcY4mVDJBc6am6GEd4KdqY3a33O86G6BP4z4rW5fNXYC2rLPXobV91bWX6MyXdYSr452hz9eXj8USr9Zv74v5ClvOVI89EM2tpFRQTyx4zx3YYqMK7hlxMi9Y7oGWpKTgwTHGNZd-o5iW6TsHns_Q7ejdhe57gNibpooW6rpsoRuiUUoVudA6gXgEbehiDODNLlRNGfaGEnOIY6I5xDFjnMTfHMXDpgH3Rx9rJOBxBPqvChow224IqUD8x_cLOX5r0w</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Jöhren, O.</creator><creator>Brüggemann, N.</creator><creator>Dominiak, P.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040601</creationdate><title>Orexins (Hypocretins) and Adrenal Function</title><author>Jöhren, O. ; Brüggemann, N. ; Dominiak, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-fe093c51141f0ceff3dec8b683f20d57827fe1a0a1efed223935fb6295149def3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenal Glands - physiology</topic><topic>Catecholamines - biosynthesis</topic><topic>Feeding Behavior - physiology</topic><topic>Gene Expression Regulation - physiology</topic><topic>Glucocorticoids - secretion</topic><topic>Humans</topic><topic>Hunger - physiology</topic><topic>Hypoglycemia - physiopathology</topic><topic>Intracellular Signaling Peptides and Proteins - physiology</topic><topic>Neuropeptides - physiology</topic><topic>Neurosecretory Systems - physiology</topic><topic>Orexin Receptors</topic><topic>Orexins</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Receptors, Neuropeptide - metabolism</topic><topic>Review</topic><topic>Sex Factors</topic><topic>Sleep - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jöhren, O.</creatorcontrib><creatorcontrib>Brüggemann, N.</creatorcontrib><creatorcontrib>Dominiak, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jöhren, O.</au><au>Brüggemann, N.</au><au>Dominiak, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orexins (Hypocretins) and Adrenal Function</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>36</volume><issue>6</issue><spage>370</spage><epage>375</epage><pages>370-375</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><abstract>Abstract
The recently discovered neuropeptides orexin A and B regulate feeding behavior, neuroendocrine and autonomic functions, and sleep-wakefulness by central mechanisms. The expression of orexins and orexin receptors in various peripheral organs and the presence of orexin A in blood indicate the existence of a peripheral orexin system. In rat and human adrenal glands, both OX
1
and OX
2
receptor subtypes have been described with a predominant expression of OX
2
receptors in the adrenal cortex. In male rats, adrenocortical OX
2
receptors are much higher expressed than in female rats. Various experimental data demonstrate a stimulatory effect of orexins on the secretion of adrenocortical steroids, mainly on glucocorticoids. Some results also suggest the regulation of catecholamine synthesis and release by orexins. Whether the gender-dependent expression of adrenocortical OX
2
receptors has functional correlates awaits future clarification. As plasma orexin appears to rise during hunger and hypoglycemia, orexins may link adrenal functions with energy homeostasis.</abstract><cop>Germany</cop><pmid>15241726</pmid><doi>10.1055/s-2004-814569</doi><tpages>6</tpages></addata></record> |
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| ispartof | Hormone and metabolic research, 2004-06, Vol.36 (6), p.370-375 |
| issn | 0018-5043 1439-4286 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adrenal Glands - physiology Catecholamines - biosynthesis Feeding Behavior - physiology Gene Expression Regulation - physiology Glucocorticoids - secretion Humans Hunger - physiology Hypoglycemia - physiopathology Intracellular Signaling Peptides and Proteins - physiology Neuropeptides - physiology Neurosecretory Systems - physiology Orexin Receptors Orexins Receptors, G-Protein-Coupled Receptors, Neuropeptide - metabolism Review Sex Factors Sleep - physiology |
| title | Orexins (Hypocretins) and Adrenal Function |
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