Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

Although jawless vertebrates are apparently capable of adaptive immune responses, they have not been found to possess the recombinatorial antigen receptors shared by all jawed vertebrates. Our search for the phylogenetic roots of adaptive immunity in the lamprey has instead identified a new type of...

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Veröffentlicht in:	Nature 2004-07, Vol.430 (6996), p.174-180
Hauptverfasser:	Cooper, Max D, Pancer, Zeev, Amemiya, Chris T, Ehrhardt, Götz R. A, Ceitlin, Jill, Larry Gartland, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Agnatha Amino Acid Motifs Amino Acid Sequence Animals Biodiversity Biological and medical sciences Biological Evolution Fish Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Rearrangement - genetics Genetics of the immune response Genome Germ-Line Mutation - genetics Glycosylphosphatidylinositols Gnathostoma Immunity - genetics Immunity - immunology Immunobiology Immunogenetics Immunology Lampreys - genetics Lampreys - immunology Lymphocyte receptors Lymphocytes Lymphocytes - immunology Lymphocytes - metabolism Models, Molecular Molecular Sequence Data Petromyzon marinus Petromyzontidae Protein Conformation Receptors, Antigen - chemistry Receptors, Antigen - genetics Receptors, Antigen - immunology Repetitive Sequences, Amino Acid RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA Vertebrates
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