Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: relationship to reduced serum TNF alpha level and increased turnover of neutrophils

Previous studies demonstrated that lactoferrin (LF), given intravenously (i.v.), 24 h before lethal Escherichia coli ( E. coli) infection, protects mice against mortality. The aim of this investigation was to determine whether downregulation of serum TNF alpha activity and increase of neutrophil num...

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Veröffentlicht in:	Inflammation research 2004-07, Vol.53 (7), p.292-296
Hauptverfasser:	Zimecki, M, Artym, J, Chodaczek, G, Kocieba, M, Kruzel, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteremia - drug therapy Bone Marrow - pathology Dose-Response Relationship, Drug Escherichia coli Escherichia coli - metabolism Escherichia coli Infections - drug therapy Escherichia coli Infections - microbiology Female Interleukin-1 - metabolism Lactoferrin - pharmacology Mice Mice, Inbred CBA Neutrophils - metabolism Sepsis Time Factors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - metabolism
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