The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle?
In a recent study, the difference between asthma and eosinophilic bronchitis (a condition characterized by cough but not airway hyperresponsiveness or airflow obstruction) was infiltration of airway smooth muscle (ASM) by mast cells. Mast cells produce a variety of lipid mediators, chemokines, cytok...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2004-07, Vol.114 (1), p.58-65 |
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| description | In a recent study, the difference between asthma and eosinophilic bronchitis (a condition characterized by cough but not airway hyperresponsiveness or airflow obstruction) was infiltration of airway smooth muscle (ASM) by mast cells. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with ASM cells to cause hyperreactivity to constrictive stimuli and proliferation, and activated ASM can produce stem cell factor and other chemokines, cytokines, and growth factors that may act in recruitment, differentiation, and retention of mast cells. Mast cell infiltration of the airways in asthma is T-cell–dependent, and TH2 cytokines from T cells and other sources act in mast cell expansion from circulating and tissue precursors. The recent data on interactions of mast cells and ASM suggest that this could be an important contributor to airway hyperresponsiveness in asthma. Why this occurs in asthma and how it is sustained remain to be established. |
| doi_str_mv | 10.1016/j.jaci.2004.03.034 |
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Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with ASM cells to cause hyperreactivity to constrictive stimuli and proliferation, and activated ASM can produce stem cell factor and other chemokines, cytokines, and growth factors that may act in recruitment, differentiation, and retention of mast cells. Mast cell infiltration of the airways in asthma is T-cell–dependent, and TH2 cytokines from T cells and other sources act in mast cell expansion from circulating and tissue precursors. The recent data on interactions of mast cells and ASM suggest that this could be an important contributor to airway hyperresponsiveness in asthma. Why this occurs in asthma and how it is sustained remain to be established.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2004.03.034</identifier><identifier>PMID: 15241345</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>airway smooth muscle ; Allergies ; Animals ; Asthma ; Asthma - immunology ; Asthma - physiopathology ; Biological and medical sciences ; Biology ; Bronchial Hyperreactivity - immunology ; Cell Survival - immunology ; chemokines ; Crystal structure ; Cytokines ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genotype & phenotype ; Histamine ; Humans ; Hypersensitivity - complications ; Hypersensitivity - immunology ; Immunoglobulin E - immunology ; Immunopathology ; Mast cells ; Mast Cells - immunology ; Mast Cells - physiology ; Medical sciences ; Mice ; Models, Animal ; Muscle, Smooth - immunology ; Phenotype ; Rodents ; Smooth muscle ; Studies</subject><ispartof>Journal of allergy and clinical immunology, 2004-07, Vol.114 (1), p.58-65</ispartof><rights>2004 American Academy of Allergy, Asthma and Immunology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 American Academy of Allergy, Asthma and Immunology</rights><rights>Copyright Elsevier Limited Jul 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-bb569044da2ab7f6f7764696e2c0ddfd8c47c568930c7498da48468f3e5990b23</citedby><cites>FETCH-LOGICAL-c485t-bb569044da2ab7f6f7764696e2c0ddfd8c47c568930c7498da48468f3e5990b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2004.03.034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15936492$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15241345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Douglas S</creatorcontrib><title>The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle?</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>In a recent study, the difference between asthma and eosinophilic bronchitis (a condition characterized by cough but not airway hyperresponsiveness or airflow obstruction) was infiltration of airway smooth muscle (ASM) by mast cells. Mast cells produce a variety of lipid mediators, chemokines, cytokines, and enzymes that may interact with ASM cells to cause hyperreactivity to constrictive stimuli and proliferation, and activated ASM can produce stem cell factor and other chemokines, cytokines, and growth factors that may act in recruitment, differentiation, and retention of mast cells. Mast cell infiltration of the airways in asthma is T-cell–dependent, and TH2 cytokines from T cells and other sources act in mast cell expansion from circulating and tissue precursors. The recent data on interactions of mast cells and ASM suggest that this could be an important contributor to airway hyperresponsiveness in asthma. Why this occurs in asthma and how it is sustained remain to be established.</description><subject>airway smooth muscle</subject><subject>Allergies</subject><subject>Animals</subject><subject>Asthma</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Cell Survival - immunology</subject><subject>chemokines</subject><subject>Crystal structure</subject><subject>Cytokines</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Genotype & phenotype</subject><subject>Histamine</subject><subject>Humans</subject><subject>Hypersensitivity - complications</subject><subject>Hypersensitivity - immunology</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Mast cells</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - physiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>Muscle, Smooth - immunology</subject><subject>Phenotype</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Studies</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNY7Lb6BXyQAdG3WfN_EimIlGoLBV_qc8gkd9gMM5M1mWnZb98Mu6D4oHDhnsDvXu7JQegtwVuCifzUb3vrwpZizLeYleIv0IZg3dRSUfESbTDWpJYN1-foIucelzdT-hU6J4JywrjYoPiwgyrFAarYVXPRo81z5WAYqjBVRe9G-7lIv7g5xGmlbEhP9lDtDntICfI-Tjk8wgQ5V-2hoDMke4Sfwryr8hhjaeOS3QBfXqOzzg4Z3pz6Jfr57ebh-ra-__H97vrrfe24EnPdtkJqzLm31LZNJ7umkVxqCdRh7zuvHG-ckEoz7Io_5S1XXKqOgdAat5Rdoo_HvfsUfy2QZzOGvNqyE8QlGymlEoyq_4KkEQxL3BTw_V9gH5c0FROGCMwVU4ryQtEj5VLMOUFn9imMNh0MwWZNzfRmTc2sqRnMSq1D706rl3YE_3vkFFMBPpwAm50dumQnF_IfnGaS69X11ZGD8rWPAZLJLsDkwIcEbjY-hn_d8QwF1rWB</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Robinson, Douglas S</creator><general>Mosby, Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle?</title><author>Robinson, Douglas S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-bb569044da2ab7f6f7764696e2c0ddfd8c47c568930c7498da48468f3e5990b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>airway smooth muscle</topic><topic>Allergies</topic><topic>Animals</topic><topic>Asthma</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biology</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Cell Survival - immunology</topic><topic>chemokines</topic><topic>Crystal structure</topic><topic>Cytokines</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Genotype & phenotype</topic><topic>Histamine</topic><topic>Humans</topic><topic>Hypersensitivity - complications</topic><topic>Hypersensitivity - immunology</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Mast cells</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - physiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Models, Animal</topic><topic>Muscle, Smooth - immunology</topic><topic>Phenotype</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Douglas S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, Douglas S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle?</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>114</volume><issue>1</issue><spage>58</spage><epage>65</epage><pages>58-65</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>In a recent study, the difference between asthma and eosinophilic bronchitis (a condition characterized by cough but not airway hyperresponsiveness or airflow obstruction) was infiltration of airway smooth muscle (ASM) by mast cells. 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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | airway smooth muscle Allergies Animals Asthma Asthma - immunology Asthma - physiopathology Biological and medical sciences Biology Bronchial Hyperreactivity - immunology Cell Survival - immunology chemokines Crystal structure Cytokines Fundamental and applied biological sciences. Psychology Fundamental immunology Genotype & phenotype Histamine Humans Hypersensitivity - complications Hypersensitivity - immunology Immunoglobulin E - immunology Immunopathology Mast cells Mast Cells - immunology Mast Cells - physiology Medical sciences Mice Models, Animal Muscle, Smooth - immunology Phenotype Rodents Smooth muscle Studies |
| title | The role of the mast cell in asthma: induction of airway hyperresponsiveness by interaction with smooth muscle? |
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