The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm
Endothelin, a potent vasoconstrictor, has been found to increase in the cerebrospinal fluid and serum of patients following subarachnoid hemorrhage (SAH) and to play a major role in the development of cerebral vasospasm. The aim of this study is to investigate the role of endothelin-A antagonist BQ-...
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| Veröffentlicht in: | Clinical autonomic research 2004-06, Vol.14 (3), p.197-201 |
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| creator | Cirak, Bayram Kiymaz, Nejmi Ari, Hasan Huseyin Ugras, Serdar |
| description | Endothelin, a potent vasoconstrictor, has been found to increase in the cerebrospinal fluid and serum of patients following subarachnoid hemorrhage (SAH) and to play a major role in the development of cerebral vasospasm. The aim of this study is to investigate the role of endothelin-A antagonist BQ-610 in the experimentally performed cerebral vasospasm following SAH. Thirty New Zealand rabbits were divided into three groups (each n = 10): group A, control group; Group B, SAH group; Group C, treatment (endothelin antagonist BQ-610 treated) group. In the study, the rabbits developed vasospasm after injection of intracisternal autolog blood into the cisterna magna. After cerebral vasospasm development, in group C, endothelin antagonist BQ-610 was injected intracisternally. Morphometrically, basilar artery lumen was constricted 25% and 62% compared to the control group (group A) in the endothelin treated group (group C) and the endothelin untreated group (group B), respectively. Histopathological findings of the basilar artery wall confirmed the therapeutic effect of endothelin antagonist in vasospasm development. Endothelin-A receptor antagonist BQ-610 has a therapeutic effect in the cerebral vasospasm following experimentally performed subarachnoid hemorrhage when used intracisternally. |
| doi_str_mv | 10.1007/s10286-004-0190-2 |
| format | Article |
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The aim of this study is to investigate the role of endothelin-A antagonist BQ-610 in the experimentally performed cerebral vasospasm following SAH. Thirty New Zealand rabbits were divided into three groups (each n = 10): group A, control group; Group B, SAH group; Group C, treatment (endothelin antagonist BQ-610 treated) group. In the study, the rabbits developed vasospasm after injection of intracisternal autolog blood into the cisterna magna. After cerebral vasospasm development, in group C, endothelin antagonist BQ-610 was injected intracisternally. Morphometrically, basilar artery lumen was constricted 25% and 62% compared to the control group (group A) in the endothelin treated group (group C) and the endothelin untreated group (group B), respectively. Histopathological findings of the basilar artery wall confirmed the therapeutic effect of endothelin antagonist in vasospasm development. 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Kiymaz, Nejmi ; Ari, Hasan Huseyin ; Ugras, Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-5c024949f8b5e3a5437c6613ae2f0b8789d3c4bfd83e106569db5118f0cbe3163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Basilar Artery - pathology</topic><topic>Blood Vessels - drug effects</topic><topic>Blood Vessels - pathology</topic><topic>Blood Vessels - physiopathology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cisterna Magna</topic><topic>Endothelin A Receptor Antagonists</topic><topic>Endothelins - antagonists & inhibitors</topic><topic>Injections</topic><topic>Oligopeptides - administration & dosage</topic><topic>Oligopeptides - therapeutic use</topic><topic>Rabbits</topic><topic>Subarachnoid Hemorrhage - drug therapy</topic><topic>Subarachnoid Hemorrhage - pathology</topic><topic>Subarachnoid Hemorrhage - physiopathology</topic><topic>Vasospasm, Intracranial - drug therapy</topic><topic>Vasospasm, Intracranial - pathology</topic><topic>Vasospasm, Intracranial - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cirak, Bayram</creatorcontrib><creatorcontrib>Kiymaz, Nejmi</creatorcontrib><creatorcontrib>Ari, Hasan Huseyin</creatorcontrib><creatorcontrib>Ugras, Serdar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical autonomic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cirak, Bayram</au><au>Kiymaz, Nejmi</au><au>Ari, Hasan Huseyin</au><au>Ugras, Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm</atitle><jtitle>Clinical autonomic research</jtitle><addtitle>Clin Auton Res</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>14</volume><issue>3</issue><spage>197</spage><epage>201</epage><pages>197-201</pages><issn>0959-9851</issn><eissn>1619-1560</eissn><coden>CAURE9</coden><abstract>Endothelin, a potent vasoconstrictor, has been found to increase in the cerebrospinal fluid and serum of patients following subarachnoid hemorrhage (SAH) and to play a major role in the development of cerebral vasospasm. 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Endothelin-A receptor antagonist BQ-610 has a therapeutic effect in the cerebral vasospasm following experimentally performed subarachnoid hemorrhage when used intracisternally.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15241650</pmid><doi>10.1007/s10286-004-0190-2</doi><tpages>5</tpages></addata></record> |
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| issn | 0959-9851 1619-1560 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Basilar Artery - pathology Blood Vessels - drug effects Blood Vessels - pathology Blood Vessels - physiopathology Cerebrovascular Circulation - drug effects Cisterna Magna Endothelin A Receptor Antagonists Endothelins - antagonists & inhibitors Injections Oligopeptides - administration & dosage Oligopeptides - therapeutic use Rabbits Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - pathology Vasospasm, Intracranial - physiopathology |
| title | The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm |
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