Alendronate in Primary Hyperparathyroidism: A Double-Blind, Randomized, Placebo-Controlled Trial

Primary hyperparathyroidism (PHPT) is often associated with reduced bone mineral density (BMD). A randomized, double-blind, placebo-controlled trial was conducted to determine whether alendronate (ALN), 10 mg daily, maintains or improves BMD in patients with PHPT. Eligible patients had asymptomatic...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2004-07, Vol.89 (7), p.3319-3325
Hauptverfasser:	Khan, Aliya A., Bilezikian, John P., Kung, Annie W. C., Ahmed, Mustafa M., Dubois, Sacha J., Ho, Andrew Y. Y., Schussheim, Debra, Rubin, Mishaela R., Shaikh, Atif M., Silverberg, Shonni J., Standish, Timothy I., Syed, Zareen, Syed, Zeba A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alendronate - therapeutic use Alendronic acid Alkaline phosphatase Alkaline Phosphatase - antagonists & inhibitors Alkaline Phosphatase - blood Asymptomatic Biological and medical sciences Biomarkers - analysis Bisphosphonates Bone and Bones - enzymology Bone density Bone Density - drug effects Bone mineral density Bone Remodeling - drug effects Bone turnover Calcium (blood) Calcium (urinary) Collagen - antagonists & inhibitors Collagen - urine Collagen Type I Double-Blind Method Dual energy X-ray absorptiometry Endocrinopathies Excretion Female Femur Femur Neck - metabolism Fundamental and applied biological sciences. Psychology Hip Hip Joint - metabolism Humans Hyperparathyroidism Hyperparathyroidism - drug therapy Hyperparathyroidism - metabolism Lumbosacral Region Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Parathyroid hormone Parathyroidectomy Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases) Patients Peptides - antagonists & inhibitors Peptides - urine Placebos Radius Radius - metabolism Spine (lumbar) Spine - metabolism Statistical analysis Vertebrates: endocrinology
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