Dendritic cells modulated by cytokine-expressing adenoviruses alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma

It has been found that TH1-related cytokines can decrease the accumulation of eosinophils in lung tissue and relieve airway constriction. Dendritic cells (DCs) have been found to prime naive T-helper cells efficiently. In this study, DCs infected with TH1 cytokine–expressing adenovirus can be used t...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2004-07, Vol.114 (1), p.88-96
Hauptverfasser:	Ye, Yi-Ling, Lee, Yueh-Lun, Chuang, Zen-Jai, Lai, Huai-Jean, Chen, Chun-Chi, Tao, Mi-Hua, Chiang, Bor-Luen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - immunology Adenovirus Animals Asthma - complications Asthma - immunology Asthma animal model Binding sites Biological and medical sciences Bone marrow Bronchial Hyperreactivity - complications Bronchial Hyperreactivity - immunology Chemokines cytokine expressing adenovirus Cytokines - immunology dendritic cell Dendritic Cells - immunology Eosinophilia - complications Eosinophilia - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Immunopathology Interleukin-12 - immunology Interleukin-18 - immunology Laboratory animals Lymphocytes Medical sciences Mice Mice, Inbred BALB C Models, Animal Th1 Cells - immunology Th2 Cells - immunology Transgenic animals
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