Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats
Six 8-week-old Sprague-Dawley rats were studied for 9 days divided into three periods of 3 days each: before transferral to metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the animals were housed in their home cages and every 6 h...
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| Veröffentlicht in: | Experimental physiology 2004-07, Vol.89 (4), p.427-433 |
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| creator | Eriksson, Emma Royo, Felix Lyberg, Karin Carlsson, Hans‐Erik Hau, Jann |
| description | Six 8-week-old Sprague-Dawley rats were studied for 9 days divided into three periods of 3 days each: before transferral to
metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the
animals were housed in their home cages and every 6 h when the animals were housed in metabolic cages during which time urine
was also collected every 6 h. The rate of weight gain was slightly reduced during the 3 days in metabolic cages and the animals
produced significantly larger amounts of faeces when housed in metabolic cages than when housed in their home cages. The total
faecal excretion of corticosterone (nanograms excreted per hour per kilogram body weight) and immunoglobulin A (IgA) (milligrams
excreted per hour per kg body weight) quantified by enzyme-linked immunosorbent assays (ELISAs) exhibited a clear diurnal
rhythm in the metabolic cage. Urinary excretions of corticosterone and IgA also followed a clear diurnal cycle. The mean daily
amounts of corticosterone excreted were not significantly affected by cage change and by housing in metabolic cages. However,
the excretion of faecal IgA was significantly reduced during the 3 days after the period in metabolic cages. Taken together
the results indicate that metabolic cage housing is mildly stressful for young adult male rats. |
| doi_str_mv | 10.1113/expphysiol.2004.027656 |
| format | Article |
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metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the
animals were housed in their home cages and every 6 h when the animals were housed in metabolic cages during which time urine
was also collected every 6 h. The rate of weight gain was slightly reduced during the 3 days in metabolic cages and the animals
produced significantly larger amounts of faeces when housed in metabolic cages than when housed in their home cages. The total
faecal excretion of corticosterone (nanograms excreted per hour per kilogram body weight) and immunoglobulin A (IgA) (milligrams
excreted per hour per kg body weight) quantified by enzyme-linked immunosorbent assays (ELISAs) exhibited a clear diurnal
rhythm in the metabolic cage. Urinary excretions of corticosterone and IgA also followed a clear diurnal cycle. The mean daily
amounts of corticosterone excreted were not significantly affected by cage change and by housing in metabolic cages. However,
the excretion of faecal IgA was significantly reduced during the 3 days after the period in metabolic cages. Taken together
the results indicate that metabolic cage housing is mildly stressful for young adult male rats.</description><identifier>ISSN: 0958-0670</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.2004.027656</identifier><identifier>PMID: 15131075</identifier><language>eng</language><publisher>9600 Garsington Road , Oxford , OX4 2DQ , UK: The Physiological Society</publisher><subject>Animals ; Circadian Rhythm - physiology ; Corticosterone - urine ; Feces ; Housing, Animal ; Immunoglobulin A - urine ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological - immunology ; Stress, Psychological - urine</subject><ispartof>Experimental physiology, 2004-07, Vol.89 (4), p.427-433</ispartof><rights>2004 The Physiological Society</rights><rights>Copyright 2004 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4376-e1720fd67c8bab3f467b6aa8562a99dbd67f0c9e0867c8295894ae410f3ceac83</citedby><cites>FETCH-LOGICAL-c4376-e1720fd67c8bab3f467b6aa8562a99dbd67f0c9e0867c8295894ae410f3ceac83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1113%2Fexpphysiol.2004.027656$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1113%2Fexpphysiol.2004.027656$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15131075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eriksson, Emma</creatorcontrib><creatorcontrib>Royo, Felix</creatorcontrib><creatorcontrib>Lyberg, Karin</creatorcontrib><creatorcontrib>Carlsson, Hans‐Erik</creatorcontrib><creatorcontrib>Hau, Jann</creatorcontrib><title>Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats</title><title>Experimental physiology</title><addtitle>Exp Physiol</addtitle><description>Six 8-week-old Sprague-Dawley rats were studied for 9 days divided into three periods of 3 days each: before transferral to
metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the
animals were housed in their home cages and every 6 h when the animals were housed in metabolic cages during which time urine
was also collected every 6 h. The rate of weight gain was slightly reduced during the 3 days in metabolic cages and the animals
produced significantly larger amounts of faeces when housed in metabolic cages than when housed in their home cages. The total
faecal excretion of corticosterone (nanograms excreted per hour per kilogram body weight) and immunoglobulin A (IgA) (milligrams
excreted per hour per kg body weight) quantified by enzyme-linked immunosorbent assays (ELISAs) exhibited a clear diurnal
rhythm in the metabolic cage. Urinary excretions of corticosterone and IgA also followed a clear diurnal cycle. The mean daily
amounts of corticosterone excreted were not significantly affected by cage change and by housing in metabolic cages. However,
the excretion of faecal IgA was significantly reduced during the 3 days after the period in metabolic cages. Taken together
the results indicate that metabolic cage housing is mildly stressful for young adult male rats.</description><subject>Animals</subject><subject>Circadian Rhythm - physiology</subject><subject>Corticosterone - urine</subject><subject>Feces</subject><subject>Housing, Animal</subject><subject>Immunoglobulin A - urine</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stress, Psychological - immunology</subject><subject>Stress, Psychological - urine</subject><issn>0958-0670</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu2zAMhoVhxZq1e4VCp92cUZYs27sVRboOKLAdVqA3QVaoRINsZZKNxm8_ZQ6Q60488ONP8iPkjsGaMca_4PFw2M_JBb8uAcQaylpW8h1ZMSHbQojq9T1ZQVs1BcgarsnHlH4DMA6N-ECuWcU4g7pakePGWjQjDZb2OOoueGeo0Tuk-zAlN-xoGKjr-2kIOx-6ybuB3lM9bKkJcXQmpBFjGJDi0UQc3YkeqNVoMP3DpuhyN8fPYcppvfZIox7TLbmy2if8dK435OVx8-vhqXj-8e37w_1zYQSvZYGsLsFuZW2aTnfcCll3UuumkqVu222XOxZMi9CckDI_3AqNgoHlBrVp-A35vOQeYvgzYRpV75JB7_WA-UMlpWxKXokMygU0MaQU0apDdL2Os2KgTs7Vxbk6OVeL8zx4d94wdT1uL2NnyRn4ugBvzuP8n7Fq8_MJhLzcv3e7_ZuLqBY4BeNwnFXTKqFEWfO_mO6jYg</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Eriksson, Emma</creator><creator>Royo, Felix</creator><creator>Lyberg, Karin</creator><creator>Carlsson, Hans‐Erik</creator><creator>Hau, Jann</creator><general>The Physiological Society</general><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats</title><author>Eriksson, Emma ; Royo, Felix ; Lyberg, Karin ; Carlsson, Hans‐Erik ; Hau, Jann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4376-e1720fd67c8bab3f467b6aa8562a99dbd67f0c9e0867c8295894ae410f3ceac83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Circadian Rhythm - physiology</topic><topic>Corticosterone - urine</topic><topic>Feces</topic><topic>Housing, Animal</topic><topic>Immunoglobulin A - urine</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stress, Psychological - immunology</topic><topic>Stress, Psychological - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksson, Emma</creatorcontrib><creatorcontrib>Royo, Felix</creatorcontrib><creatorcontrib>Lyberg, Karin</creatorcontrib><creatorcontrib>Carlsson, Hans‐Erik</creatorcontrib><creatorcontrib>Hau, Jann</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksson, Emma</au><au>Royo, Felix</au><au>Lyberg, Karin</au><au>Carlsson, Hans‐Erik</au><au>Hau, Jann</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats</atitle><jtitle>Experimental physiology</jtitle><addtitle>Exp Physiol</addtitle><date>2004-07</date><risdate>2004</risdate><volume>89</volume><issue>4</issue><spage>427</spage><epage>433</epage><pages>427-433</pages><issn>0958-0670</issn><eissn>1469-445X</eissn><abstract>Six 8-week-old Sprague-Dawley rats were studied for 9 days divided into three periods of 3 days each: before transferral to
metabolism cages, during metabolic cage housing and after return to their home cages. Faeces were collected daily when the
animals were housed in their home cages and every 6 h when the animals were housed in metabolic cages during which time urine
was also collected every 6 h. The rate of weight gain was slightly reduced during the 3 days in metabolic cages and the animals
produced significantly larger amounts of faeces when housed in metabolic cages than when housed in their home cages. The total
faecal excretion of corticosterone (nanograms excreted per hour per kilogram body weight) and immunoglobulin A (IgA) (milligrams
excreted per hour per kg body weight) quantified by enzyme-linked immunosorbent assays (ELISAs) exhibited a clear diurnal
rhythm in the metabolic cage. Urinary excretions of corticosterone and IgA also followed a clear diurnal cycle. The mean daily
amounts of corticosterone excreted were not significantly affected by cage change and by housing in metabolic cages. However,
the excretion of faecal IgA was significantly reduced during the 3 days after the period in metabolic cages. Taken together
the results indicate that metabolic cage housing is mildly stressful for young adult male rats.</abstract><cop>9600 Garsington Road , Oxford , OX4 2DQ , UK</cop><pub>The Physiological Society</pub><pmid>15131075</pmid><doi>10.1113/expphysiol.2004.027656</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental physiology, 2004-07, Vol.89 (4), p.427-433 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library; Wiley Online Library Free Content |
| subjects | Animals Circadian Rhythm - physiology Corticosterone - urine Feces Housing, Animal Immunoglobulin A - urine Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Male Rats Rats, Sprague-Dawley Stress, Psychological - immunology Stress, Psychological - urine |
| title | Effect of metabolic cage housing on immunoglobulin A and corticosterone excretion in faeces and urine of young male rats |
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