Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma
Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumo...
Gespeichert in:
| Veröffentlicht in: | Pathology, research and practice research and practice, 2004-01, Vol.200 (5), p.379-387 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 387 |
|---|---|
| container_issue | 5 |
| container_start_page | 379 |
| container_title | Pathology, research and practice |
| container_volume | 200 |
| creator | Sis, Banu Saǧol, Özgul Küpelioǧlu, Ali Sokmen, Selman Terzi, Cem Fuzun, Mehmet Özer, Erdener Bishop, Paul |
| description | Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer.
Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival.
Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (
p=0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (
p=0.006) and stage (
p=0.03). CD expression was related to depth of invasion (
p=0.005). No significant relationship was found between survival and MMP-2 and CD expression (
p>0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (
p>0.05).
Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival. |
| doi_str_mv | 10.1016/j.prp.2004.02.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66681879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033804000743</els_id><sourcerecordid>66681879</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-5e50902b944d9038bd5e2013c93e8b9766d021b9f58081267c6c6be2c7c1f1723</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EokvhA3BBFgdOTTpjJ04iTmj500qV4ABny3EmxavEDnaC2m-PV7sSEgdOI8383tPoPcZeI5QIqK4P5RKXUgBUJYgSUDxhO1TYFqAkPmU7kFVVgJTtBXuR0gEAGqjwObvAWshOVmrHtm8x3PuQVmd5cvfejc4ab4mHkc9mje6Bz7SaaQpLDCs5bxIV4opbs_6kJTnPP15x4we-Uj5Z54s9p4clUkoueJ7vNkwhks0eWRQzEWbzkj0bzZTo1Xlesh-fP33f3xR3X7_c7j_cFbZqcC1qqqED0XdVNXQg236oSQBK20lq-65RagCBfTfWLbQoVGOVVT0J21gcsRHykr07-ebnf22UVj27ZGmajKewJa2UarFtugy-_Qc8hC36_JsWUNdCSDxCeIJsDClFGvUS3Wzio0bQx0L0IW8WfSxEg9C5kKx5czbe-pmGv4pzAxl4fwIo5_DbUdQ5RcoNDO6Ymh6C-4_9HxWtm5o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205522319</pqid></control><display><type>article</type><title>Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Sis, Banu ; Saǧol, Özgul ; Küpelioǧlu, Ali ; Sokmen, Selman ; Terzi, Cem ; Fuzun, Mehmet ; Özer, Erdener ; Bishop, Paul</creator><creatorcontrib>Sis, Banu ; Saǧol, Özgul ; Küpelioǧlu, Ali ; Sokmen, Selman ; Terzi, Cem ; Fuzun, Mehmet ; Özer, Erdener ; Bishop, Paul</creatorcontrib><description>Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer.
Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival.
Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (
p=0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (
p=0.006) and stage (
p=0.03). CD expression was related to depth of invasion (
p=0.005). No significant relationship was found between survival and MMP-2 and CD expression (
p>0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (
p>0.05).
Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2004.02.012</identifier><identifier>PMID: 15239346</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adenocarcinoma - metabolism ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Cathepsin D - biosynthesis ; Cathepsin-D ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Female ; History, 17th Century ; Humans ; Immunohistochemistry ; Lymphatic Metastasis - pathology ; Male ; Matrix Metalloproteinase 2 - biosynthesis ; Matrix metalloproteinase-2 ; Prognosis ; Survival Analysis ; Tenascin - biosynthesis ; Tenascin-C</subject><ispartof>Pathology, research and practice, 2004-01, Vol.200 (5), p.379-387</ispartof><rights>2004 Elsevier GmbH</rights><rights>Copyright Urban & Fischer Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5e50902b944d9038bd5e2013c93e8b9766d021b9f58081267c6c6be2c7c1f1723</citedby><cites>FETCH-LOGICAL-c471t-5e50902b944d9038bd5e2013c93e8b9766d021b9f58081267c6c6be2c7c1f1723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/205522319?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15239346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sis, Banu</creatorcontrib><creatorcontrib>Saǧol, Özgul</creatorcontrib><creatorcontrib>Küpelioǧlu, Ali</creatorcontrib><creatorcontrib>Sokmen, Selman</creatorcontrib><creatorcontrib>Terzi, Cem</creatorcontrib><creatorcontrib>Fuzun, Mehmet</creatorcontrib><creatorcontrib>Özer, Erdener</creatorcontrib><creatorcontrib>Bishop, Paul</creatorcontrib><title>Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer.
Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival.
Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (
p=0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (
p=0.006) and stage (
p=0.03). CD expression was related to depth of invasion (
p=0.005). No significant relationship was found between survival and MMP-2 and CD expression (
p>0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (
p>0.05).
Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival.</description><subject>Adenocarcinoma - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cathepsin D - biosynthesis</subject><subject>Cathepsin-D</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>History, 17th Century</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - biosynthesis</subject><subject>Matrix metalloproteinase-2</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Tenascin - biosynthesis</subject><subject>Tenascin-C</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU9v1DAQxS0EokvhA3BBFgdOTTpjJ04iTmj500qV4ABny3EmxavEDnaC2m-PV7sSEgdOI8383tPoPcZeI5QIqK4P5RKXUgBUJYgSUDxhO1TYFqAkPmU7kFVVgJTtBXuR0gEAGqjwObvAWshOVmrHtm8x3PuQVmd5cvfejc4ab4mHkc9mje6Bz7SaaQpLDCs5bxIV4opbs_6kJTnPP15x4we-Uj5Z54s9p4clUkoueJ7vNkwhks0eWRQzEWbzkj0bzZTo1Xlesh-fP33f3xR3X7_c7j_cFbZqcC1qqqED0XdVNXQg236oSQBK20lq-65RagCBfTfWLbQoVGOVVT0J21gcsRHykr07-ebnf22UVj27ZGmajKewJa2UarFtugy-_Qc8hC36_JsWUNdCSDxCeIJsDClFGvUS3Wzio0bQx0L0IW8WfSxEg9C5kKx5czbe-pmGv4pzAxl4fwIo5_DbUdQ5RcoNDO6Ymh6C-4_9HxWtm5o</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Sis, Banu</creator><creator>Saǧol, Özgul</creator><creator>Küpelioǧlu, Ali</creator><creator>Sokmen, Selman</creator><creator>Terzi, Cem</creator><creator>Fuzun, Mehmet</creator><creator>Özer, Erdener</creator><creator>Bishop, Paul</creator><general>Elsevier GmbH</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma</title><author>Sis, Banu ; Saǧol, Özgul ; Küpelioǧlu, Ali ; Sokmen, Selman ; Terzi, Cem ; Fuzun, Mehmet ; Özer, Erdener ; Bishop, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5e50902b944d9038bd5e2013c93e8b9766d021b9f58081267c6c6be2c7c1f1723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cathepsin D - biosynthesis</topic><topic>Cathepsin-D</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>History, 17th Century</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - biosynthesis</topic><topic>Matrix metalloproteinase-2</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Tenascin - biosynthesis</topic><topic>Tenascin-C</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sis, Banu</creatorcontrib><creatorcontrib>Saǧol, Özgul</creatorcontrib><creatorcontrib>Küpelioǧlu, Ali</creatorcontrib><creatorcontrib>Sokmen, Selman</creatorcontrib><creatorcontrib>Terzi, Cem</creatorcontrib><creatorcontrib>Fuzun, Mehmet</creatorcontrib><creatorcontrib>Özer, Erdener</creatorcontrib><creatorcontrib>Bishop, Paul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sis, Banu</au><au>Saǧol, Özgul</au><au>Küpelioǧlu, Ali</au><au>Sokmen, Selman</au><au>Terzi, Cem</au><au>Fuzun, Mehmet</au><au>Özer, Erdener</au><au>Bishop, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>200</volume><issue>5</issue><spage>379</spage><epage>387</epage><pages>379-387</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in degrading the components of basement membrane and extracellular matrix (ECM), whereas tenascin-C (TN-C) is a glycoprotein of the ECM related to cell adhesion and detachment. These proteins have been implicated in tumor invasion and metastasis. Therefore, we aimed at investigating the prognostic significance of MMP-2, CD, and TN-C expressions in primary colorectal cancer.
Overall, 112 colorectal adenocarcinomas were included in the present study. MMP-2, CD, and TN-C expressions were evaluated by immunohistochemistry and correlated with clinicopathologic prognostic parameters and survival.
Diffuse stromal TN-C immunostaining was found to be significantly correlated with advanced stage and shorter survival time (
p=0.002 and 0.02, respectively). MMP-2 expression was found to correlate with lymph vessel invasion (
p=0.006) and stage (
p=0.03). CD expression was related to depth of invasion (
p=0.005). No significant relationship was found between survival and MMP-2 and CD expression (
p>0.05). In multivariate analysis, stage and vascular invasion were independent prognostic factors, whereas TN-C did not retain a clear independent relationship to survival (
p>0.05).
Our findings suggest that TN-C expression may be a potential prognostic marker in colorectal carcinoma. However, MMP-2 and CD do not appear to be significant indicators of survival.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>15239346</pmid><doi>10.1016/j.prp.2004.02.012</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 2004-01, Vol.200 (5), p.379-387 |
| issn | 0344-0338 1618-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66681879 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Adenocarcinoma - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Cathepsin D - biosynthesis Cathepsin-D Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female History, 17th Century Humans Immunohistochemistry Lymphatic Metastasis - pathology Male Matrix Metalloproteinase 2 - biosynthesis Matrix metalloproteinase-2 Prognosis Survival Analysis Tenascin - biosynthesis Tenascin-C |
| title | Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T08%3A23%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20significance%20of%20matrix%20metalloproteinase-2,%20cathepsin%20D,%20and%20tenascin-C%20expression%20in%20colorectal%20carcinoma&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Sis,%20Banu&rft.date=2004-01-01&rft.volume=200&rft.issue=5&rft.spage=379&rft.epage=387&rft.pages=379-387&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/j.prp.2004.02.012&rft_dat=%3Cproquest_cross%3E66681879%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205522319&rft_id=info:pmid/15239346&rft_els_id=S0344033804000743&rfr_iscdi=true |