Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa
Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%)...
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| Veröffentlicht in: | Journal of ethnopharmacology 2004-08, Vol.93 (2), p.331-335 |
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| container_title | Journal of ethnopharmacology |
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| creator | Lohombo-Ekomba, M-L Okusa, P.N Penge, O Kabongo, C Choudhary, M.Iqbal Kasende, O.E |
| description | Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and
N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of
Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine. |
| doi_str_mv | 10.1016/j.jep.2004.04.006 |
| format | Article |
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N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of
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N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of
Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine.</description><subject>Albertisia villosa</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antibacterial activity</subject><subject>Antifungal activity</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Antimalarials - administration & dosage</subject><subject>Antimalarials - pharmacology</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiplasmodial activity</subject><subject>Biological and medical sciences</subject><subject>Cytotoxic activity</subject><subject>General pharmacology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Medical sciences</subject><subject>Menispermaceae</subject><subject>Microbial Sensitivity Tests</subject><subject>Mitosporic Fungi - drug effects</subject><subject>Parasitic Sensitivity Tests</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Traditional medicine</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7uzqD_AifdHT9ljppDtpPA2LX7DgRQ-eQk26IhkynTHJDLv_3gzToiehIAn1vEXqYewVhzUHPrzbrXd0WHcAcn0uGJ6wFdeqa1WvxFO2AqF0q5XkV-w65x0AKC7hObvifSekUmLFfmzm4rdoCyWP4bbB-nTH-eef-yFg3sdp6U2NfSyxxAdvm5rxJ1885Sa6ZhO2lIrPHpuTDyFmfMGeOQyZXi7nDfv-8cO3u8_t_ddPX-42960Vaizt6LTopOSuHwl0t3W9tDiJiVuNoB3XBKi4RoUWZA9c9JPUaiDoFfG6rLhhby9zDyn-OlIuZu-zpRBwpnjMZhgGzUHoCvILaFPMOZEzh-T3mB4NB3P2aXam-jRnn-ZcMNTM62X4cbun6W9iEViBNwuA2WJwCWfr8z_cKOU4jJV7f-Goqjh5SiZbT7OlySeyxUzR_-cbvwFI_JLm</recordid><startdate>20040801</startdate><enddate>20040801</enddate><creator>Lohombo-Ekomba, M-L</creator><creator>Okusa, P.N</creator><creator>Penge, O</creator><creator>Kabongo, C</creator><creator>Choudhary, M.Iqbal</creator><creator>Kasende, O.E</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040801</creationdate><title>Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa</title><author>Lohombo-Ekomba, M-L ; Okusa, P.N ; Penge, O ; Kabongo, C ; Choudhary, M.Iqbal ; Kasende, O.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-9f832441f59e082bf54cad3d1c8a08f18e0a718a7ac0450135d4876e057e11873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Albertisia villosa</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibacterial activity</topic><topic>Antifungal activity</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Antimalarials - administration & dosage</topic><topic>Antimalarials - pharmacology</topic><topic>Antimalarials - therapeutic use</topic><topic>Antiplasmodial activity</topic><topic>Biological and medical sciences</topic><topic>Cytotoxic activity</topic><topic>General pharmacology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Medical sciences</topic><topic>Menispermaceae</topic><topic>Microbial Sensitivity Tests</topic><topic>Mitosporic Fungi - drug effects</topic><topic>Parasitic Sensitivity Tests</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Traditional medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lohombo-Ekomba, M-L</creatorcontrib><creatorcontrib>Okusa, P.N</creatorcontrib><creatorcontrib>Penge, O</creatorcontrib><creatorcontrib>Kabongo, C</creatorcontrib><creatorcontrib>Choudhary, M.Iqbal</creatorcontrib><creatorcontrib>Kasende, O.E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lohombo-Ekomba, M-L</au><au>Okusa, P.N</au><au>Penge, O</au><au>Kabongo, C</au><au>Choudhary, M.Iqbal</au><au>Kasende, O.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2004-08-01</date><risdate>2004</risdate><volume>93</volume><issue>2</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and
N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of
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| subjects | Albertisia villosa Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Infective Agents - administration & dosage Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antibacterial activity Antifungal activity Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antimalarials - administration & dosage Antimalarials - pharmacology Antimalarials - therapeutic use Antiplasmodial activity Biological and medical sciences Cytotoxic activity General pharmacology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Malaria, Falciparum - drug therapy Medical sciences Menispermaceae Microbial Sensitivity Tests Mitosporic Fungi - drug effects Parasitic Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Plasmodium falciparum - drug effects Traditional medicine |
| title | Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa |
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