Studies on the trypanocidal activity of semi-synthetic pyran[ b-4,3]naphtho[1,2- d]imidazoles from β-lapachone

We synthesized new naphthoimidazoles from β-lapachone with an aromatic moiety linked to the imidazole ring, using phenylic and heterocyclic aldehydes. The most active compound against Trypanosoma cruzi had a p-methyl group linked to the phenyl ring, presenting an EC 50 value of 15.5 ± 2.9 μM. No rel...

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