Post-exposure prophylaxis of systemic anthrax in mice and treatment with fluoroquinolones

Objectives: To compare the fluoroquinolones gatifloxacin and moxifloxacin with ciprofloxacin for post-exposure prophylaxis of systemic anthrax in a BALB/c mouse model. Methods: Treated mice and controls were inoculated subcutaneously with 5×104 spores/mouse of Bacillus anthracis Ames strain and obse...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2004-07, Vol.54 (1), p.95-99
Hauptverfasser:	Steward, J., Lever, M. S., Simpson, A. J. H., Sefton, A. M., Brooks, T. J. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax - microbiology Anthrax - prevention & control Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Aza Compounds - pharmacokinetics Aza Compounds - therapeutic use Bacillus anthracis Bacillus anthracis - drug effects Biological and medical sciences Ciprofloxacin - pharmacokinetics Ciprofloxacin - therapeutic use Female Fluoroquinolones - pharmacokinetics Fluoroquinolones - therapeutic use Medical sciences Mice Mice, Inbred BALB C Microbial Sensitivity Tests murine model Pharmacology. Drug treatments Quinolines - pharmacokinetics Quinolines - therapeutic use quinolones Survival Analysis therapy
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