Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma

The activities of three N -acetylglucosaminyltransferases (GnT)-III, IV and V, as well as the structural alterations of N-glycans on the glycoproteins in cancer tissues and bile specimens from 28 cases of extrahepatic bile duct carcinoma (EBDC) were compared with those from 18 cases of benign biliar...

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Veröffentlicht in:	Glycoconjugate journal 2003-01, Vol.20 (6), p.399-406
Hauptverfasser:	Jin, Xiao-Ling, Liu, Hou-Bao, Zhang, Ying, Wang, Bing-Sheng, Chen, Hui-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bile Bile Duct Diseases - enzymology Bile Duct Neoplasms - enzymology Bile ducts Bile Ducts, Extrahepatic - enzymology Blotting, Western Cancer Carcinoma - enzymology Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glycoproteins Glycosylation High-performance liquid chromatography Humans Lectins - chemistry Lectins - metabolism Male Middle Aged N-Acetylglucosaminyltransferases - metabolism N-Acetylglucosinyldiphosphodolichol N-acetylglucosaminyltransferase N-glycans Neuraminidase - metabolism Polysaccharides Polysaccharides - chemistry Prognosis Substrate Specificity Up-Regulation
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