Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat
Low‐fat diets and diets containing n−3 fatty acids (FA) slow the progression of renal injury in the male Han:Sprague‐Dawley (SPRD)‐cy rat model of polycystic kidney disease. To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this st...
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| description | Low‐fat diets and diets containing n−3 fatty acids (FA) slow the progression of renal injury in the male Han:Sprague‐Dawley (SPRD)‐cy rat model of polycystic kidney disease. To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female pcy mice to examine the effects of fat level and type on disease progression. Adult pcy mice were fed 4, 10, or 20 g soybean oil/100 g diet for 130 d in study 1. In study 2, weanling pcy mice were fed high or low levels of fat rich in 18∶2n−6 (corn oil, CO) 18∶3n−3 (flaxseed oil/CO 4∶1 g/g, FO), or 22∶6n−3 (algal oil/CO 4∶1 g/g, DO) for 8 wk. In adult pcy mice, low‐compared with high‐fat diets lowered kidney weights (2.4±0.2 vs. 3.1±0.2 g/100 g body weight, P=0.006) and serum urea nitrogen (SUN) (9.6±0.6 vs. 11.9±0.6 mmol/L, P=0.009), whereas in young pcy mice it reduced renal fibrosis volumes (0.44±0.04 vs. 0.62±0.04 mL/kg body weight, P |
| doi_str_mv | 10.1007/s11745-004-1221-7 |
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To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female pcy mice to examine the effects of fat level and type on disease progression. Adult pcy mice were fed 4, 10, or 20 g soybean oil/100 g diet for 130 d in study 1. In study 2, weanling pcy mice were fed high or low levels of fat rich in 18∶2n−6 (corn oil, CO) 18∶3n−3 (flaxseed oil/CO 4∶1 g/g, FO), or 22∶6n−3 (algal oil/CO 4∶1 g/g, DO) for 8 wk. In adult pcy mice, low‐compared with high‐fat diets lowered kidney weights (2.4±0.2 vs. 3.1±0.2 g/100 g body weight, P=0.006) and serum urea nitrogen (SUN) (9.6±0.6 vs. 11.9±0.6 mmol/L, P=0.009), whereas in young pcy mice it reduced renal fibrosis volumes (0.44±0.04 vs. 0.62±0.04 mL/kg body weight, P<0.0001). FO feeding in young pcy mice mitigated the detrimental effects of high fat on fibrosis while not altering kidney size, function, and oxidative damage when compared with the CO‐fed mice. In contrast, DO‐compared with CO‐fed mice had higher kidney weights (2.64±0.07 vs. 2.24±0.08 g/100 g body weight, P=0.005), SUN (9.4±0.57 vs. 7.0±0.62 nmol/L, P<0.0001), and cyst volumes (7.9±0.28 vs. 6.2±0.30 mL/kg body weight, P<0.0001) and similar levels of oxidative damage and fibrosis. The FA compositions of the diets were reflected in the kidneys: 18∶2n−6, 18∶3n−3, and 22∶6n−3 were the highest in the CO, FO, and DO diets, respectively. Dietary effects on kidney disease progression were similar in males and females. A low‐fat diet slows progression of renal injury in male and female pcy mice, consistent with findings in the male Han:SPRD‐cy rat. Dietary fat type also influenced renal injury, with flaxseed oil diets rich in 18∶3n−3 slowing early fibrosis progression compared with diets rich in 18∶2n−6 or in 22∶6n−3.</description><identifier>ISSN: 0024-4201</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-004-1221-7</identifier><identifier>PMID: 15233398</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>animal disease models ; Animal Feed ; Animals ; Body weight ; Corn Oil - pharmacology ; Diet ; dietary fat ; Docosahexaenoic Acids - pharmacology ; Fatty acids ; Fatty Acids - analysis ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Acids, Omega-3 - chemistry ; Fatty Acids, Omega-3 - therapeutic use ; Female ; Females ; Fibrosis ; Flaxseed oil ; gender differences ; Kidney - chemistry ; Kidney - pathology ; Kidney diseases ; Kidneys ; Linseed Oil - pharmacology ; Male ; Mice ; Mice, Mutant Strains ; Nutrition ; omega-3 fatty acids ; Organ Size ; polycystic kidney disease ; Polycystic Kidney Diseases - drug therapy ; Polycystic Kidney Diseases - metabolism ; Polycystic Kidney Diseases - pathology ; Proteins - genetics ; renal fibrosis ; Rodents ; Soybean oil ; Soybeans ; TRPP Cation Channels ; Urea</subject><ispartof>Lipids, 2004-03, Vol.39 (3), p.207-214</ispartof><rights>2004 American Oil Chemists' Society (AOCS)</rights><rights>AOCS Press 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4627-aa9003af901e87621a33a3e457dbf33b2273a320a1781fa64c0dd00de00eb4f83</citedby><cites>FETCH-LOGICAL-c4627-aa9003af901e87621a33a3e457dbf33b2273a320a1781fa64c0dd00de00eb4f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-004-1221-7$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-004-1221-7$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15233398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sankaran, D</creatorcontrib><creatorcontrib>Lu, J</creatorcontrib><creatorcontrib>Bankovic-Calic, N</creatorcontrib><creatorcontrib>Ogborn, M.R</creatorcontrib><creatorcontrib>Aukema, H.M</creatorcontrib><title>Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat</title><title>Lipids</title><addtitle>Lipids</addtitle><description>Low‐fat diets and diets containing n−3 fatty acids (FA) slow the progression of renal injury in the male Han:Sprague‐Dawley (SPRD)‐cy rat model of polycystic kidney disease. To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female pcy mice to examine the effects of fat level and type on disease progression. Adult pcy mice were fed 4, 10, or 20 g soybean oil/100 g diet for 130 d in study 1. In study 2, weanling pcy mice were fed high or low levels of fat rich in 18∶2n−6 (corn oil, CO) 18∶3n−3 (flaxseed oil/CO 4∶1 g/g, FO), or 22∶6n−3 (algal oil/CO 4∶1 g/g, DO) for 8 wk. In adult pcy mice, low‐compared with high‐fat diets lowered kidney weights (2.4±0.2 vs. 3.1±0.2 g/100 g body weight, P=0.006) and serum urea nitrogen (SUN) (9.6±0.6 vs. 11.9±0.6 mmol/L, P=0.009), whereas in young pcy mice it reduced renal fibrosis volumes (0.44±0.04 vs. 0.62±0.04 mL/kg body weight, P<0.0001). FO feeding in young pcy mice mitigated the detrimental effects of high fat on fibrosis while not altering kidney size, function, and oxidative damage when compared with the CO‐fed mice. In contrast, DO‐compared with CO‐fed mice had higher kidney weights (2.64±0.07 vs. 2.24±0.08 g/100 g body weight, P=0.005), SUN (9.4±0.57 vs. 7.0±0.62 nmol/L, P<0.0001), and cyst volumes (7.9±0.28 vs. 6.2±0.30 mL/kg body weight, P<0.0001) and similar levels of oxidative damage and fibrosis. The FA compositions of the diets were reflected in the kidneys: 18∶2n−6, 18∶3n−3, and 22∶6n−3 were the highest in the CO, FO, and DO diets, respectively. Dietary effects on kidney disease progression were similar in males and females. A low‐fat diet slows progression of renal injury in male and female pcy mice, consistent with findings in the male Han:SPRD‐cy rat. Dietary fat type also influenced renal injury, with flaxseed oil diets rich in 18∶3n−3 slowing early fibrosis progression compared with diets rich in 18∶2n−6 or in 22∶6n−3.</description><subject>animal disease models</subject><subject>Animal Feed</subject><subject>Animals</subject><subject>Body weight</subject><subject>Corn Oil - pharmacology</subject><subject>Diet</subject><subject>dietary fat</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Fatty acids</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Acids, Omega-3 - chemistry</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Female</subject><subject>Females</subject><subject>Fibrosis</subject><subject>Flaxseed oil</subject><subject>gender differences</subject><subject>Kidney - chemistry</subject><subject>Kidney - pathology</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Linseed Oil - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Nutrition</subject><subject>omega-3 fatty acids</subject><subject>Organ Size</subject><subject>polycystic kidney disease</subject><subject>Polycystic Kidney Diseases - drug therapy</subject><subject>Polycystic Kidney Diseases - metabolism</subject><subject>Polycystic Kidney Diseases - pathology</subject><subject>Proteins - genetics</subject><subject>renal fibrosis</subject><subject>Rodents</subject><subject>Soybean oil</subject><subject>Soybeans</subject><subject>TRPP Cation Channels</subject><subject>Urea</subject><issn>0024-4201</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU9v1DAQxS0EotvCB-ACFgdugfGfxM4RtVAqbVUk6Nly4nHxKuuEOAHl2-MoKyH10tPTjH7vjTSPkDcMPjIA9SkxpmRZAMiCcc4K9YzsWFnqohagnpMdAJeF5MDOyHlKhzwyWZcvyRkruRCi1jsy3_Zu7uwU-kh7T0eMtqMhHuZxyUKHdqHH0CJtFuoCTjavvZ1o28fJhhjiA42FWFfTQm0bXKIOB4xZc-D0C2mHf7CjNjo6LQOuNzL8irzwtkv4-qQX5P7rl5-X34r93fXN5ed90cqKq8LaGkBYXwNDrSrOrBBWoCyVa7wQDecqzxwsU5p5W8kWnANwCICN9FpckA9b7jD2v2dMkzmG1GLX2Yj9nExVVapmIDL4_hF46Ocx_yIZrTUTJdRlhtgGtWOf0ojeDGM45pcYBmYtxGyFmFyIWQsxKnvenoLn5ojuv-PUQAbUBvwNHS5PJ5r9zfcr4LBGv9uc3vbGPowhmfsfuWwBUFcCdCX-AaaNnqA</recordid><startdate>200403</startdate><enddate>200403</enddate><creator>Sankaran, D</creator><creator>Lu, J</creator><creator>Bankovic-Calic, N</creator><creator>Ogborn, M.R</creator><creator>Aukema, H.M</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200403</creationdate><title>Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat</title><author>Sankaran, D ; Lu, J ; Bankovic-Calic, N ; Ogborn, M.R ; Aukema, H.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4627-aa9003af901e87621a33a3e457dbf33b2273a320a1781fa64c0dd00de00eb4f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>animal disease models</topic><topic>Animal Feed</topic><topic>Animals</topic><topic>Body weight</topic><topic>Corn Oil - pharmacology</topic><topic>Diet</topic><topic>dietary fat</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Fatty acids</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Acids, Omega-3 - chemistry</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Female</topic><topic>Females</topic><topic>Fibrosis</topic><topic>Flaxseed oil</topic><topic>gender differences</topic><topic>Kidney - chemistry</topic><topic>Kidney - pathology</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Linseed Oil - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Nutrition</topic><topic>omega-3 fatty acids</topic><topic>Organ Size</topic><topic>polycystic kidney disease</topic><topic>Polycystic Kidney Diseases - drug therapy</topic><topic>Polycystic Kidney Diseases - metabolism</topic><topic>Polycystic Kidney Diseases - pathology</topic><topic>Proteins - genetics</topic><topic>renal fibrosis</topic><topic>Rodents</topic><topic>Soybean oil</topic><topic>Soybeans</topic><topic>TRPP Cation Channels</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sankaran, D</creatorcontrib><creatorcontrib>Lu, J</creatorcontrib><creatorcontrib>Bankovic-Calic, N</creatorcontrib><creatorcontrib>Ogborn, M.R</creatorcontrib><creatorcontrib>Aukema, H.M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sankaran, D</au><au>Lu, J</au><au>Bankovic-Calic, N</au><au>Ogborn, M.R</au><au>Aukema, H.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2004-03</date><risdate>2004</risdate><volume>39</volume><issue>3</issue><spage>207</spage><epage>214</epage><pages>207-214</pages><issn>0024-4201</issn><eissn>1558-9307</eissn><abstract>Low‐fat diets and diets containing n−3 fatty acids (FA) slow the progression of renal injury in the male Han:Sprague‐Dawley (SPRD)‐cy rat model of polycystic kidney disease. To determine whether these dietary fat effects are similar in females and in another model of renal cystic disease, in this study we used both male and female pcy mice to examine the effects of fat level and type on disease progression. Adult pcy mice were fed 4, 10, or 20 g soybean oil/100 g diet for 130 d in study 1. In study 2, weanling pcy mice were fed high or low levels of fat rich in 18∶2n−6 (corn oil, CO) 18∶3n−3 (flaxseed oil/CO 4∶1 g/g, FO), or 22∶6n−3 (algal oil/CO 4∶1 g/g, DO) for 8 wk. In adult pcy mice, low‐compared with high‐fat diets lowered kidney weights (2.4±0.2 vs. 3.1±0.2 g/100 g body weight, P=0.006) and serum urea nitrogen (SUN) (9.6±0.6 vs. 11.9±0.6 mmol/L, P=0.009), whereas in young pcy mice it reduced renal fibrosis volumes (0.44±0.04 vs. 0.62±0.04 mL/kg body weight, P<0.0001). FO feeding in young pcy mice mitigated the detrimental effects of high fat on fibrosis while not altering kidney size, function, and oxidative damage when compared with the CO‐fed mice. In contrast, DO‐compared with CO‐fed mice had higher kidney weights (2.64±0.07 vs. 2.24±0.08 g/100 g body weight, P=0.005), SUN (9.4±0.57 vs. 7.0±0.62 nmol/L, P<0.0001), and cyst volumes (7.9±0.28 vs. 6.2±0.30 mL/kg body weight, P<0.0001) and similar levels of oxidative damage and fibrosis. The FA compositions of the diets were reflected in the kidneys: 18∶2n−6, 18∶3n−3, and 22∶6n−3 were the highest in the CO, FO, and DO diets, respectively. Dietary effects on kidney disease progression were similar in males and females. A low‐fat diet slows progression of renal injury in male and female pcy mice, consistent with findings in the male Han:SPRD‐cy rat. Dietary fat type also influenced renal injury, with flaxseed oil diets rich in 18∶3n−3 slowing early fibrosis progression compared with diets rich in 18∶2n−6 or in 22∶6n−3.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>15233398</pmid><doi>10.1007/s11745-004-1221-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Lipids, 2004-03, Vol.39 (3), p.207-214 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SpringerLink Journals |
| subjects | animal disease models Animal Feed Animals Body weight Corn Oil - pharmacology Diet dietary fat Docosahexaenoic Acids - pharmacology Fatty acids Fatty Acids - analysis Fatty Acids, Omega-3 - administration & dosage Fatty Acids, Omega-3 - chemistry Fatty Acids, Omega-3 - therapeutic use Female Females Fibrosis Flaxseed oil gender differences Kidney - chemistry Kidney - pathology Kidney diseases Kidneys Linseed Oil - pharmacology Male Mice Mice, Mutant Strains Nutrition omega-3 fatty acids Organ Size polycystic kidney disease Polycystic Kidney Diseases - drug therapy Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - pathology Proteins - genetics renal fibrosis Rodents Soybean oil Soybeans TRPP Cation Channels Urea |
| title | Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat |
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