Simultaneous Assessment of Gastric Accommodation and Emptying: Studies with Liquid and Solid Meals

The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously. Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 2004-07, Vol.45 (7), p.1155-1160
Hauptverfasser: Simonian, Hrair P, Maurer, Alan H, Knight, Linda C, Kantor, Steve, Kontos, Despina, Megalooikonomou, Vasileios, Fisher, Robert S, Parkman, Henry P
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container_issue 7
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container_title The Journal of nuclear medicine (1978)
container_volume 45
creator Simonian, Hrair P
Maurer, Alan H
Knight, Linda C
Kantor, Steve
Kontos, Despina
Megalooikonomou, Vasileios
Fisher, Robert S
Parkman, Henry P
description The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously. Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) (99m)Tc-pertechnetate. After ingestion of 11 MBq (300 micro Ci) (111)In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an (111)In-oxine-labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image. With the liquid nutrient drink (9 subjects), maximal mean CSA (158% +/- 12% of baseline; P < 0.05) occurred 40 min after meal ingestion, when only 69% +/- 3% of the radiolabeled liquid nutrient drink remained in the stomach. At 120 min, mean CSA was 125% +/- 8% of baseline, but only 35% +/- 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% +/- 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% +/- 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% +/- 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% +/- 19% of baseline). This method permits simultaneous measurement of gastric emptying and accommodation. In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal.
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At 120 min, mean CSA was 125% +/- 8% of baseline, but only 35% +/- 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% +/- 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% +/- 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% +/- 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% +/- 19% of baseline). This method permits simultaneous measurement of gastric emptying and accommodation. 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Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) (99m)Tc-pertechnetate. After ingestion of 11 MBq (300 micro Ci) (111)In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an (111)In-oxine-labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image. With the liquid nutrient drink (9 subjects), maximal mean CSA (158% +/- 12% of baseline; P &lt; 0.05) occurred 40 min after meal ingestion, when only 69% +/- 3% of the radiolabeled liquid nutrient drink remained in the stomach. 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In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>15235061</pmid><tpages>6</tpages></addata></record>
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subjects Administration, Oral
Adult
Anatomy, Cross-Sectional - methods
Dyspepsia - diagnostic imaging
Dyspepsia - physiopathology
Female
Gastric Emptying - physiology
Gastrointestinal Motility - physiology
Humans
Image Interpretation, Computer-Assisted - methods
Injections, Intravenous
Male
Octreotide - administration & dosage
Octreotide - analogs & derivatives
Organometallic Compounds - administration & dosage
Oxyquinoline - administration & dosage
Oxyquinoline - analogs & derivatives
Pentetic Acid - administration & dosage
Pentetic Acid - analogs & derivatives
Phantoms, Imaging
Radionuclide Imaging
Radiopharmaceuticals - administration & dosage
Reproducibility of Results
Sensitivity and Specificity
Sodium Pertechnetate Tc 99m - administration & dosage
Stomach - diagnostic imaging
Stomach - physiology
title Simultaneous Assessment of Gastric Accommodation and Emptying: Studies with Liquid and Solid Meals
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