Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans
The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NO x) level, endothelial function, and blood pressure (BP) remains unclear. We estimated the relationship of eNOS polymorphisms (the T −786C in the 5′-flanking promoter region, T −786C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp i...
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| Veröffentlicht in: | American journal of hypertension 2004-07, Vol.17 (7), p.560-567 |
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| creator | Li, Rongling Lyn, Deborah Lapu-Bula, Rigobert Oduwole, Adefisayo Igho-Pemu, Priscilla Lankford, Brenda Morgan, Jan Nkemdechi, Sunday Liu, Gang Pack, Cheryl Silvestrov, Natalia von Deutsch, Daniel A. Song, Qing Abukhalaf, Imad K. Ofili, Elizabeth |
| description | The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NO
x) level, endothelial function, and blood pressure (BP) remains unclear.
We estimated the relationship of eNOS polymorphisms (the T
−786C in the 5′-flanking promoter region, T
−786C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp in exon 7, G894T) with plasma NO
x level, brachial endothelial function assessed by ultrasound measure of brachial artery flow-mediated dilation (FMD), and BP in 60 healthy African Americans, 30 men and 30 women aged 18 to 73 years.
Among them, 73.1%, 23.9%, and 3.0% carried TT, TC, and CC of T
−786C, respectively, 14.5%, 27.5%, 53.6%, and 1.4% carried aa, ab, bb, and bc of eNOS4 polymorphism, respectively, and 70.4%, 23.9%, and 5.6% carried GG, GT, and TT of G894T, respectively. G894T and eNOS4 were observed in linkage disequilibrium. Mean values of age, plasma NO
x, FMD, systolic and diastolic BPs were not significantly different (
P > .05) by eNOS polymorphisms. Plasma NO
x level was found to be associated with systolic BP (
r = 0.51,
P = .03), and diastolic BP (
r = 0.41,
P = .08), but not with FMD, in individuals with “a” allele of eNOS4 polymorphism after adjustment for age, body mass index, serum glucose, and smoking status.
We reveal a positive association between plasma NO
x level and BP in normotensive African Americans who carry the “a” allele of eNOS4. Because the frequency of the rare allele “a” is significantly higher in African Americans than in other ethnic groups, this finding may provide a clue to understanding the genetic susceptibility to hypertension in African Americans. |
| doi_str_mv | 10.1016/j.amjhyper.2004.02.013 |
| format | Article |
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x) level, endothelial function, and blood pressure (BP) remains unclear.
We estimated the relationship of eNOS polymorphisms (the T
−786C in the 5′-flanking promoter region, T
−786C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp in exon 7, G894T) with plasma NO
x level, brachial endothelial function assessed by ultrasound measure of brachial artery flow-mediated dilation (FMD), and BP in 60 healthy African Americans, 30 men and 30 women aged 18 to 73 years.
Among them, 73.1%, 23.9%, and 3.0% carried TT, TC, and CC of T
−786C, respectively, 14.5%, 27.5%, 53.6%, and 1.4% carried aa, ab, bb, and bc of eNOS4 polymorphism, respectively, and 70.4%, 23.9%, and 5.6% carried GG, GT, and TT of G894T, respectively. G894T and eNOS4 were observed in linkage disequilibrium. Mean values of age, plasma NO
x, FMD, systolic and diastolic BPs were not significantly different (
P > .05) by eNOS polymorphisms. Plasma NO
x level was found to be associated with systolic BP (
r = 0.51,
P = .03), and diastolic BP (
r = 0.41,
P = .08), but not with FMD, in individuals with “a” allele of eNOS4 polymorphism after adjustment for age, body mass index, serum glucose, and smoking status.
We reveal a positive association between plasma NO
x level and BP in normotensive African Americans who carry the “a” allele of eNOS4. Because the frequency of the rare allele “a” is significantly higher in African Americans than in other ethnic groups, this finding may provide a clue to understanding the genetic susceptibility to hypertension in African Americans.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1879-1905</identifier><identifier>EISSN: 1941-7225</identifier><identifier>DOI: 10.1016/j.amjhyper.2004.02.013</identifier><identifier>PMID: 15233974</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; African Americans ; Aged ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Biomarkers - blood ; Black or African American ; Black People ; Blood and lymphatic vessels ; Blood Flow Velocity - physiology ; blood pressure ; Blood Pressure - physiology ; Cardiology. Vascular system ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - physiopathology ; Diastole - physiology ; endothelial function ; endothelial nitric oxide synthase gene ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - physiology ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Genotype ; Georgia - epidemiology ; Humans ; Male ; Medical sciences ; Middle Aged ; nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase - genetics ; Nitric Oxide Synthase Type III ; Polymorphism, Genetic - genetics ; Risk Factors ; Statistics as Topic ; Systole - physiology ; Vasodilation - physiology</subject><ispartof>American journal of hypertension, 2004-07, Vol.17 (7), p.560-567</ispartof><rights>2004 American Journal of Hypertension, Ltd.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15925756$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15233974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Rongling</creatorcontrib><creatorcontrib>Lyn, Deborah</creatorcontrib><creatorcontrib>Lapu-Bula, Rigobert</creatorcontrib><creatorcontrib>Oduwole, Adefisayo</creatorcontrib><creatorcontrib>Igho-Pemu, Priscilla</creatorcontrib><creatorcontrib>Lankford, Brenda</creatorcontrib><creatorcontrib>Morgan, Jan</creatorcontrib><creatorcontrib>Nkemdechi, Sunday</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Pack, Cheryl</creatorcontrib><creatorcontrib>Silvestrov, Natalia</creatorcontrib><creatorcontrib>von Deutsch, Daniel A.</creatorcontrib><creatorcontrib>Song, Qing</creatorcontrib><creatorcontrib>Abukhalaf, Imad K.</creatorcontrib><creatorcontrib>Ofili, Elizabeth</creatorcontrib><title>Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans</title><title>American journal of hypertension</title><addtitle>AJH</addtitle><description>The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NO
x) level, endothelial function, and blood pressure (BP) remains unclear.
We estimated the relationship of eNOS polymorphisms (the T
−786C in the 5′-flanking promoter region, T
−786C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp in exon 7, G894T) with plasma NO
x level, brachial endothelial function assessed by ultrasound measure of brachial artery flow-mediated dilation (FMD), and BP in 60 healthy African Americans, 30 men and 30 women aged 18 to 73 years.
Among them, 73.1%, 23.9%, and 3.0% carried TT, TC, and CC of T
−786C, respectively, 14.5%, 27.5%, 53.6%, and 1.4% carried aa, ab, bb, and bc of eNOS4 polymorphism, respectively, and 70.4%, 23.9%, and 5.6% carried GG, GT, and TT of G894T, respectively. G894T and eNOS4 were observed in linkage disequilibrium. Mean values of age, plasma NO
x, FMD, systolic and diastolic BPs were not significantly different (
P > .05) by eNOS polymorphisms. Plasma NO
x level was found to be associated with systolic BP (
r = 0.51,
P = .03), and diastolic BP (
r = 0.41,
P = .08), but not with FMD, in individuals with “a” allele of eNOS4 polymorphism after adjustment for age, body mass index, serum glucose, and smoking status.
We reveal a positive association between plasma NO
x level and BP in normotensive African Americans who carry the “a” allele of eNOS4. Because the frequency of the rare allele “a” is significantly higher in African Americans than in other ethnic groups, this finding may provide a clue to understanding the genetic susceptibility to hypertension in African Americans.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Flow Velocity - physiology</subject><subject>blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cardiovascular Diseases - metabolism</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Diastole - physiology</subject><subject>endothelial function</subject><subject>endothelial nitric oxide synthase gene</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Georgia - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - genetics</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><subject>Systole - physiology</subject><subject>Vasodilation - physiology</subject><issn>0895-7061</issn><issn>1879-1905</issn><issn>1941-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkt1u1DAQhS0EokvhFSpLCK6a4J_ESe4oFbRUlZBakBA3ltcZs14cO7WTqvsSPDNedotabmZGmm-ORkcHoSNKSkqoeLcu1bBebUaIJSOkKgkrCeVP0IK2TVfQjtRP0YK0XV00RNAD9CKlNcmgEPQ5OqA147xrqgX6fQVOTTZ4HAwG34dpBc4qh72dotU43NkecNr4aaUS4J_gAU8Bj06lQT2GHNyCO34kYmavt-LHWPkeL10IPR4jpDRHwNbjE5PPVe4D_B3SS_TMKJfg1b4fom-fPn49PS8uv5x9Pj25LIALMhVgiGqpAFpRShQVmgmTZ24IXRLBWt12xtSG5cKzXbzr6xYq2nPRatJ3ih-itzvdMYabGdIkB5s0OKc8hDlJIUTTVlWdwdf_geswR59_k5QwUVddQ0WmjvbUvBygl2O0g4obee9zBt7sAZW0ciYqr216wHWsbuqtULHjbJrg7t9exV9SNLyp5fn3H_KCsA9n7PpKXmf-_Y6HbNathSiTtuA19DaCnmQfbP5TbiMj1_I-MnIbGUmYzNbwP6SxtVs</recordid><startdate>20040701</startdate><enddate>20040701</enddate><creator>Li, Rongling</creator><creator>Lyn, Deborah</creator><creator>Lapu-Bula, Rigobert</creator><creator>Oduwole, Adefisayo</creator><creator>Igho-Pemu, Priscilla</creator><creator>Lankford, Brenda</creator><creator>Morgan, Jan</creator><creator>Nkemdechi, Sunday</creator><creator>Liu, Gang</creator><creator>Pack, Cheryl</creator><creator>Silvestrov, Natalia</creator><creator>von Deutsch, Daniel A.</creator><creator>Song, Qing</creator><creator>Abukhalaf, Imad K.</creator><creator>Ofili, Elizabeth</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>Elsevier Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20040701</creationdate><title>Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans</title><author>Li, Rongling ; Lyn, Deborah ; Lapu-Bula, Rigobert ; Oduwole, Adefisayo ; Igho-Pemu, Priscilla ; Lankford, Brenda ; Morgan, Jan ; Nkemdechi, Sunday ; Liu, Gang ; Pack, Cheryl ; Silvestrov, Natalia ; von Deutsch, Daniel A. ; Song, Qing ; Abukhalaf, Imad K. ; Ofili, Elizabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e360t-ef0a816e14110a16c26f1413f01b0628c89ff5f2ff5310139d58e41d368c0d9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Flow Velocity - physiology</topic><topic>blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cardiovascular Diseases - metabolism</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Diastole - physiology</topic><topic>endothelial function</topic><topic>endothelial nitric oxide synthase gene</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Georgia - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - genetics</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Risk Factors</topic><topic>Statistics as Topic</topic><topic>Systole - physiology</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rongling</creatorcontrib><creatorcontrib>Lyn, Deborah</creatorcontrib><creatorcontrib>Lapu-Bula, Rigobert</creatorcontrib><creatorcontrib>Oduwole, Adefisayo</creatorcontrib><creatorcontrib>Igho-Pemu, Priscilla</creatorcontrib><creatorcontrib>Lankford, Brenda</creatorcontrib><creatorcontrib>Morgan, Jan</creatorcontrib><creatorcontrib>Nkemdechi, Sunday</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><creatorcontrib>Pack, Cheryl</creatorcontrib><creatorcontrib>Silvestrov, Natalia</creatorcontrib><creatorcontrib>von Deutsch, Daniel A.</creatorcontrib><creatorcontrib>Song, Qing</creatorcontrib><creatorcontrib>Abukhalaf, Imad K.</creatorcontrib><creatorcontrib>Ofili, Elizabeth</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Rongling</au><au>Lyn, Deborah</au><au>Lapu-Bula, Rigobert</au><au>Oduwole, Adefisayo</au><au>Igho-Pemu, Priscilla</au><au>Lankford, Brenda</au><au>Morgan, Jan</au><au>Nkemdechi, Sunday</au><au>Liu, Gang</au><au>Pack, Cheryl</au><au>Silvestrov, Natalia</au><au>von Deutsch, Daniel A.</au><au>Song, Qing</au><au>Abukhalaf, Imad K.</au><au>Ofili, Elizabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans</atitle><jtitle>American journal of hypertension</jtitle><addtitle>AJH</addtitle><date>2004-07-01</date><risdate>2004</risdate><volume>17</volume><issue>7</issue><spage>560</spage><epage>567</epage><pages>560-567</pages><issn>0895-7061</issn><eissn>1879-1905</eissn><eissn>1941-7225</eissn><coden>AJHYE6</coden><abstract>The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NO
x) level, endothelial function, and blood pressure (BP) remains unclear.
We estimated the relationship of eNOS polymorphisms (the T
−786C in the 5′-flanking promoter region, T
−786C; 27-bp repeat in intron 4, eNOS4; and Glu298Asp in exon 7, G894T) with plasma NO
x level, brachial endothelial function assessed by ultrasound measure of brachial artery flow-mediated dilation (FMD), and BP in 60 healthy African Americans, 30 men and 30 women aged 18 to 73 years.
Among them, 73.1%, 23.9%, and 3.0% carried TT, TC, and CC of T
−786C, respectively, 14.5%, 27.5%, 53.6%, and 1.4% carried aa, ab, bb, and bc of eNOS4 polymorphism, respectively, and 70.4%, 23.9%, and 5.6% carried GG, GT, and TT of G894T, respectively. G894T and eNOS4 were observed in linkage disequilibrium. Mean values of age, plasma NO
x, FMD, systolic and diastolic BPs were not significantly different (
P > .05) by eNOS polymorphisms. Plasma NO
x level was found to be associated with systolic BP (
r = 0.51,
P = .03), and diastolic BP (
r = 0.41,
P = .08), but not with FMD, in individuals with “a” allele of eNOS4 polymorphism after adjustment for age, body mass index, serum glucose, and smoking status.
We reveal a positive association between plasma NO
x level and BP in normotensive African Americans who carry the “a” allele of eNOS4. Because the frequency of the rare allele “a” is significantly higher in African Americans than in other ethnic groups, this finding may provide a clue to understanding the genetic susceptibility to hypertension in African Americans.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15233974</pmid><doi>10.1016/j.amjhyper.2004.02.013</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0895-7061 |
| ispartof | American journal of hypertension, 2004-07, Vol.17 (7), p.560-567 |
| issn | 0895-7061 1879-1905 1941-7225 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66678445 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Adult African Americans Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Black or African American Black People Blood and lymphatic vessels Blood Flow Velocity - physiology blood pressure Blood Pressure - physiology Cardiology. Vascular system Cardiovascular Diseases - genetics Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Diastole - physiology endothelial function endothelial nitric oxide synthase gene Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Female Gene Frequency - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genotype Georgia - epidemiology Humans Male Medical sciences Middle Aged nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Polymorphism, Genetic - genetics Risk Factors Statistics as Topic Systole - physiology Vasodilation - physiology |
| title | Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans |
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