Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5% Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana
Black cohosh (Cimicifuga racemosa) is used to treat discomfort during menopause and as a substitute for synthetic drugs in hormone replacement therapy. The mostly wildcrafted plant is ranked among the top-selling herbs in the United States. There is a risk for adulteration with the similar-looking C...
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| Veröffentlicht in: | Journal of AOAC International 2008-11, Vol.91 (6), p.1257-1264 |
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| creator | Ankli, Anita Reich, Eike Steiner, Mario |
| description | Black cohosh (Cimicifuga racemosa) is used to treat discomfort during menopause and as a substitute for synthetic drugs in hormone replacement therapy. The mostly wildcrafted plant is ranked among the top-selling herbs in the United States. There is a risk for adulteration with the similar-looking C. americana, which grows in the same habitats of the eastern United States. Other adulterants found in today's global marketplace are the 3 Asian Cimicifuga species C. foetida, C. heracleifolia, and C. dahurica. A very practical, rapid, and reliable high-performance thin-layer chromatographic (HPTLC) method was developed for identification of C. racemosa and detection of its most common adulterants by fingerprint profiles. With specific derivatization reagents, mixtures of C. racemosa with a minimum of 5% of one of the adulterants can be detected. The proposed method was validated with respect to specificity, stability, precision, and robustness. It can be used for quality control of black cohosh raw material in a current Good Manufacturing Practices environment. |
| doi_str_mv | 10.1093/jaoac/91.6.1257 |
| format | Article |
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The mostly wildcrafted plant is ranked among the top-selling herbs in the United States. There is a risk for adulteration with the similar-looking C. americana, which grows in the same habitats of the eastern United States. Other adulterants found in today's global marketplace are the 3 Asian Cimicifuga species C. foetida, C. heracleifolia, and C. dahurica. A very practical, rapid, and reliable high-performance thin-layer chromatographic (HPTLC) method was developed for identification of C. racemosa and detection of its most common adulterants by fingerprint profiles. With specific derivatization reagents, mixtures of C. racemosa with a minimum of 5% of one of the adulterants can be detected. The proposed method was validated with respect to specificity, stability, precision, and robustness. It can be used for quality control of black cohosh raw material in a current Good Manufacturing Practices environment.</description><identifier>ISSN: 1060-3271</identifier><identifier>EISSN: 1944-7922</identifier><identifier>DOI: 10.1093/jaoac/91.6.1257</identifier><identifier>PMID: 19202784</identifier><language>eng</language><publisher>Gaithersburg, MD: AOAC International</publisher><subject>Actaea ; Actaea americana ; Actaea dahurica ; Actaea heracleifolia ; Actaea racemosa ; adulterated products ; Antimony - chemistry ; Biological and medical sciences ; Boric Acids - chemistry ; Caulophyllum - chemistry ; Chromatography, Thin Layer ; Cimicifuga - chemistry ; Densitometry ; Drug Contamination ; food contamination ; Food industries ; Fundamental and applied biological sciences. Psychology ; General aspects ; herbal medicines ; herbs ; hormone supplements ; Indicators and Reagents ; medicinal plants ; Methods of analysis, processing and quality control, regulation, standards ; Oxalic Acid - chemistry ; Plant Extracts - analysis ; Plant Preparations - analysis ; rapid methods ; Reference Standards ; Solutions ; Species Specificity ; Spectrophotometry, Ultraviolet ; Tablets ; thin layer chromatography</subject><ispartof>Journal of AOAC International, 2008-11, Vol.91 (6), p.1257-1264</ispartof><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2008 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-f51b0a798648ae6c01b62bb364ed40eafdfe28d8af264fc4fea6b1ced8d410363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21002224$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19202784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ankli, Anita</creatorcontrib><creatorcontrib>Reich, Eike</creatorcontrib><creatorcontrib>Steiner, Mario</creatorcontrib><title>Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5% Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana</title><title>Journal of AOAC International</title><addtitle>J AOAC Int</addtitle><description>Black cohosh (Cimicifuga racemosa) is used to treat discomfort during menopause and as a substitute for synthetic drugs in hormone replacement therapy. The mostly wildcrafted plant is ranked among the top-selling herbs in the United States. There is a risk for adulteration with the similar-looking C. americana, which grows in the same habitats of the eastern United States. Other adulterants found in today's global marketplace are the 3 Asian Cimicifuga species C. foetida, C. heracleifolia, and C. dahurica. A very practical, rapid, and reliable high-performance thin-layer chromatographic (HPTLC) method was developed for identification of C. racemosa and detection of its most common adulterants by fingerprint profiles. With specific derivatization reagents, mixtures of C. racemosa with a minimum of 5% of one of the adulterants can be detected. The proposed method was validated with respect to specificity, stability, precision, and robustness. It can be used for quality control of black cohosh raw material in a current Good Manufacturing Practices environment.</description><subject>Actaea</subject><subject>Actaea americana</subject><subject>Actaea dahurica</subject><subject>Actaea heracleifolia</subject><subject>Actaea racemosa</subject><subject>adulterated products</subject><subject>Antimony - chemistry</subject><subject>Biological and medical sciences</subject><subject>Boric Acids - chemistry</subject><subject>Caulophyllum - chemistry</subject><subject>Chromatography, Thin Layer</subject><subject>Cimicifuga - chemistry</subject><subject>Densitometry</subject><subject>Drug Contamination</subject><subject>food contamination</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>herbal medicines</subject><subject>herbs</subject><subject>hormone supplements</subject><subject>Indicators and Reagents</subject><subject>medicinal plants</subject><subject>Methods of analysis, processing and quality control, regulation, standards</subject><subject>Oxalic Acid - chemistry</subject><subject>Plant Extracts - analysis</subject><subject>Plant Preparations - analysis</subject><subject>rapid methods</subject><subject>Reference Standards</subject><subject>Solutions</subject><subject>Species Specificity</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tablets</subject><subject>thin layer chromatography</subject><issn>1060-3271</issn><issn>1944-7922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9v1DAQxSMEoqVw5ga-lBPZtR3HiY9L-FOkRSBoz9HEHm9cknhrJ0L9WHxDvN0F5IM9T783ntHLspeMrhhVxfoWPOi1Yiu5YrysHmXnTAmRV4rzx-lNJc0LXrGz7FmMt5QKJil_mp0xxSmvanGe_f4Oe2fIldv1-TcM1ocRJo3kundTvoV7DKTpgx9h9rsA-95p8gXn3huSUPIeZ9Sz8xPxlpSXZGOWYcYAf6V3A-ifpPG9jz355eaeNG502tllB6kBzs7AW9KsSJ9MekBn_eCOioF-CU6nIv2TahjxUE7wPHtiYYj44nRfZDcfP1w3V_n266fPzWaba8HVnNuSdRQqVUtRA0pNWSd51xVSoBEUwRqLvDY1WC6F1cIiyI5pNLURjBayuMjeHPvug79bMM7t6KLGYYAJ_RJbKWVVSi4SuDqCOxiwdZP1c1omHYNpVz-hdUnfMMXqsqKKJ8P6aNDBxxjQtvvgRgj3LaPtIdb2IdZWsVa2h1iT49VplqUb0fznTzkm4PIEQNQw2JBCdPEfxxmlnD_M-vrIWfAt7EJibn5wygrKSsXKoiz-AFfJthU</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Ankli, Anita</creator><creator>Reich, Eike</creator><creator>Steiner, Mario</creator><general>AOAC International</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5% Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana</title><author>Ankli, Anita ; Reich, Eike ; Steiner, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-f51b0a798648ae6c01b62bb364ed40eafdfe28d8af264fc4fea6b1ced8d410363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Actaea</topic><topic>Actaea americana</topic><topic>Actaea dahurica</topic><topic>Actaea heracleifolia</topic><topic>Actaea racemosa</topic><topic>adulterated products</topic><topic>Antimony - chemistry</topic><topic>Biological and medical sciences</topic><topic>Boric Acids - chemistry</topic><topic>Caulophyllum - chemistry</topic><topic>Chromatography, Thin Layer</topic><topic>Cimicifuga - chemistry</topic><topic>Densitometry</topic><topic>Drug Contamination</topic><topic>food contamination</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>herbal medicines</topic><topic>herbs</topic><topic>hormone supplements</topic><topic>Indicators and Reagents</topic><topic>medicinal plants</topic><topic>Methods of analysis, processing and quality control, regulation, standards</topic><topic>Oxalic Acid - chemistry</topic><topic>Plant Extracts - analysis</topic><topic>Plant Preparations - analysis</topic><topic>rapid methods</topic><topic>Reference Standards</topic><topic>Solutions</topic><topic>Species Specificity</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets</topic><topic>thin layer chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ankli, Anita</creatorcontrib><creatorcontrib>Reich, Eike</creatorcontrib><creatorcontrib>Steiner, Mario</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of AOAC International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ankli, Anita</au><au>Reich, Eike</au><au>Steiner, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5% Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana</atitle><jtitle>Journal of AOAC International</jtitle><addtitle>J AOAC Int</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>91</volume><issue>6</issue><spage>1257</spage><epage>1264</epage><pages>1257-1264</pages><issn>1060-3271</issn><eissn>1944-7922</eissn><abstract>Black cohosh (Cimicifuga racemosa) is used to treat discomfort during menopause and as a substitute for synthetic drugs in hormone replacement therapy. The mostly wildcrafted plant is ranked among the top-selling herbs in the United States. There is a risk for adulteration with the similar-looking C. americana, which grows in the same habitats of the eastern United States. Other adulterants found in today's global marketplace are the 3 Asian Cimicifuga species C. foetida, C. heracleifolia, and C. dahurica. A very practical, rapid, and reliable high-performance thin-layer chromatographic (HPTLC) method was developed for identification of C. racemosa and detection of its most common adulterants by fingerprint profiles. With specific derivatization reagents, mixtures of C. racemosa with a minimum of 5% of one of the adulterants can be detected. The proposed method was validated with respect to specificity, stability, precision, and robustness. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Actaea Actaea americana Actaea dahurica Actaea heracleifolia Actaea racemosa adulterated products Antimony - chemistry Biological and medical sciences Boric Acids - chemistry Caulophyllum - chemistry Chromatography, Thin Layer Cimicifuga - chemistry Densitometry Drug Contamination food contamination Food industries Fundamental and applied biological sciences. Psychology General aspects herbal medicines herbs hormone supplements Indicators and Reagents medicinal plants Methods of analysis, processing and quality control, regulation, standards Oxalic Acid - chemistry Plant Extracts - analysis Plant Preparations - analysis rapid methods Reference Standards Solutions Species Specificity Spectrophotometry, Ultraviolet Tablets thin layer chromatography |
| title | Rapid High-Performance Thin-Layer Chromatographic Method for Detection of 5% Adulteration of Black Cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana |
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