Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism

Solid tumors depend on angiogenesis for sustained growth. Tissue inhibitor of metalloproteinase 2 (TIMP-2) is an angiogenesis inhibitor initially characterized for its ability to block matrix metalloproteinases; however, recent data suggest that the antiangiogenic action of TIMP-2 may rely on matrix...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-07, Vol.64 (13), p.4481-4486
Hauptverfasser:	FELDMAN, Andrew L, STETLER-STEVENSON, William G, O'CONNOR, Sarah, LIBUTTI, Steven K, COSTOUROS, Nick G, KNEZEVIC, Vladimir, BAIBAKOV, Galina, ALEXANDER, H. Richard, LORANG, Dominique, HEWITT, Stephen M, SEO, Dong-Wan, MILLER, Marshall S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Cycle Proteins Cell Division - physiology Colonic Neoplasms - blood supply Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Dual Specificity Phosphatase 1 Enzyme Induction Female Gene Expression Profiling Immediate-Early Proteins - biosynthesis Medical sciences Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology p38 Mitogen-Activated Protein Kinases Pharmacology. Drug treatments Phosphoprotein Phosphatases Phosphorylation Protein Phosphatase 1 Protein Tyrosine Phosphatases - biosynthesis Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - physiology Transduction, Genetic Tumors
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