Host cell protein clearance during protein a chromatography: Development of an improved column wash step
Host cell protein (HCP) contaminant clearance is a significant concern during downstream process development for biopharmaceuticals. Protein A chromatography as a capture step for monoclonal antibodies and Fc fusion proteins can clear a large proportion of these impurities from cell culture harvest....
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Veröffentlicht in: | Biotechnology progress 2008-09, Vol.24 (5), p.1115-1121 |
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Sprache: | eng |
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