Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice
The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage-, Sca1++, c-kit+ (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait loci (QTL) have been identified in young mice. Because...
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| Veröffentlicht in: | Blood 2004-07, Vol.104 (2), p.374-379 |
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| creator | Henckaerts, Els Langer, Jessica C. Snoeck, Hans-Willem |
| description | The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage-, Sca1++, c-kit+ (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait loci (QTL) have been identified in young mice. Because some traits affecting hematopoiesis also change with age in a mouse strain-dependent fashion, we performed quantitative trait analysis in aged BXD recombinant inbred (RI) mice for the number and frequency of LSK cells, and for their proliferative capacity in vitro. Several novel QTL were identified. The number and frequency of LSK cells in old mice correlated inversely with lifespan. Furthermore, 4 of 7 lifespan QTL overlap with QTL contributing to the number, frequency, or proliferative capacity of LSK cells in young or old mice. Taken together, these data establish a close genetic, and perhaps functional, link between genetic variation in lifespan and characteristics of stem and progenitor cells. (Blood. 2004;104:374-379) |
| doi_str_mv | 10.1182/blood-2003-12-4304 |
| format | Article |
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Because some traits affecting hematopoiesis also change with age in a mouse strain-dependent fashion, we performed quantitative trait analysis in aged BXD recombinant inbred (RI) mice for the number and frequency of LSK cells, and for their proliferative capacity in vitro. Several novel QTL were identified. The number and frequency of LSK cells in old mice correlated inversely with lifespan. Furthermore, 4 of 7 lifespan QTL overlap with QTL contributing to the number, frequency, or proliferative capacity of LSK cells in young or old mice. Taken together, these data establish a close genetic, and perhaps functional, link between genetic variation in lifespan and characteristics of stem and progenitor cells. 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Psychology ; Genetic Linkage ; Genetic Variation ; Hematopoiesis - genetics ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - physiology ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mice, Mutant Strains ; Molecular and cellular biology ; Nerve Tissue Proteins - genetics ; Nuclear Proteins - genetics ; Proto-Oncogene Proteins c-kit - genetics ; Quantitative Trait, Heritable ; Recombinant Proteins - genetics</subject><ispartof>Blood, 2004-07, Vol.104 (2), p.374-379</ispartof><rights>2004 American Society of Hematology</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-9b053eedca187cbbc325f03055e20fa3a9603faf2d2e9f0db766bb0870daa3953</citedby><cites>FETCH-LOGICAL-c426t-9b053eedca187cbbc325f03055e20fa3a9603faf2d2e9f0db766bb0870daa3953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15998099$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14988159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henckaerts, Els</creatorcontrib><creatorcontrib>Langer, Jessica C.</creatorcontrib><creatorcontrib>Snoeck, Hans-Willem</creatorcontrib><title>Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice</title><title>Blood</title><addtitle>Blood</addtitle><description>The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage-, Sca1++, c-kit+ (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait loci (QTL) have been identified in young mice. Because some traits affecting hematopoiesis also change with age in a mouse strain-dependent fashion, we performed quantitative trait analysis in aged BXD recombinant inbred (RI) mice for the number and frequency of LSK cells, and for their proliferative capacity in vitro. Several novel QTL were identified. The number and frequency of LSK cells in old mice correlated inversely with lifespan. Furthermore, 4 of 7 lifespan QTL overlap with QTL contributing to the number, frequency, or proliferative capacity of LSK cells in young or old mice. Taken together, these data establish a close genetic, and perhaps functional, link between genetic variation in lifespan and characteristics of stem and progenitor cells. (Blood. 2004;104:374-379)</description><subject>Aging - genetics</subject><subject>Animals</subject><subject>Ataxin-1</subject><subject>Ataxins</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - physiology</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell Lineage - physiology</subject><subject>Cell physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Linkage</subject><subject>Genetic Variation</subject><subject>Hematopoiesis - genetics</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Mice, Mutant Strains</subject><subject>Molecular and cellular biology</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nuclear Proteins - genetics</subject><subject>Proto-Oncogene Proteins c-kit - genetics</subject><subject>Quantitative Trait, Heritable</subject><subject>Recombinant Proteins - genetics</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxhtR3HH1BTxILnprraS7M93gRde_sCCCgrdQSVe70XTSJumBfSsf0fTMwN48FXz1q4-q-qrqKYeXnPfilXYhjLUAaGou6raB9l61453oawAB96sdAMi6Hfb8onqU0i8A3jaie1hd8Hboe94Nu-rv1xV9thmzPRD7SZ6yNeyA0RYleGY9yzfEbmjGHJZgj-2UaWaGnGPoR7bEUOZsDvGkmTAvGPNMPh_7xcLZidKCnmEkZlxI5G6L6H_TyDCzeXXZLo6YC8Zu_Nsf71ikYqStL-sVSceCztbQ4-rBhC7Rk3O9rL5_eP_t6lN9_eXj56s317Vphcz1oKFriEaDvN8brU05fIIGuo4ETNjgIKGZcBKjoGGCUe-l1Br6PYyIzdA1l9WLk285789KKavZpu0-9BTWpKSU-0ZIWUBxAk0MKUWa1BLtjPFWcVBbTuqYk9pyUlyoLacy9OzsvuqZxruRczAFeH4GMBl0U0RvbLrjumHoYdi41yeOyi8OlqJKxpI3NNrywKzGYP-3xz_rlrV0</recordid><startdate>20040715</startdate><enddate>20040715</enddate><creator>Henckaerts, Els</creator><creator>Langer, Jessica C.</creator><creator>Snoeck, Hans-Willem</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040715</creationdate><title>Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice</title><author>Henckaerts, Els ; Langer, Jessica C. ; Snoeck, Hans-Willem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-9b053eedca187cbbc325f03055e20fa3a9603faf2d2e9f0db766bb0870daa3953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aging - genetics</topic><topic>Animals</topic><topic>Ataxin-1</topic><topic>Ataxins</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells - cytology</topic><topic>Bone Marrow Cells - physiology</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell Lineage - physiology</topic><topic>Cell physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Linkage</topic><topic>Genetic Variation</topic><topic>Hematopoiesis - genetics</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Mice, Mutant Strains</topic><topic>Molecular and cellular biology</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nuclear Proteins - genetics</topic><topic>Proto-Oncogene Proteins c-kit - genetics</topic><topic>Quantitative Trait, Heritable</topic><topic>Recombinant Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henckaerts, Els</creatorcontrib><creatorcontrib>Langer, Jessica C.</creatorcontrib><creatorcontrib>Snoeck, Hans-Willem</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henckaerts, Els</au><au>Langer, Jessica C.</au><au>Snoeck, Hans-Willem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2004-07-15</date><risdate>2004</risdate><volume>104</volume><issue>2</issue><spage>374</spage><epage>379</epage><pages>374-379</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>The number of bone marrow hematopoietic stem and progenitor cells as defined by the lineage-, Sca1++, c-kit+ (LSK) phenotype and their proliferative capacity in vitro are subject to quantitative genetic variation, and several quantitative trait loci (QTL) have been identified in young mice. Because some traits affecting hematopoiesis also change with age in a mouse strain-dependent fashion, we performed quantitative trait analysis in aged BXD recombinant inbred (RI) mice for the number and frequency of LSK cells, and for their proliferative capacity in vitro. Several novel QTL were identified. The number and frequency of LSK cells in old mice correlated inversely with lifespan. Furthermore, 4 of 7 lifespan QTL overlap with QTL contributing to the number, frequency, or proliferative capacity of LSK cells in young or old mice. Taken together, these data establish a close genetic, and perhaps functional, link between genetic variation in lifespan and characteristics of stem and progenitor cells. (Blood. 2004;104:374-379)</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>14988159</pmid><doi>10.1182/blood-2003-12-4304</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging - genetics Animals Ataxin-1 Ataxins Biological and medical sciences Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cell differentiation, maturation, development, hematopoiesis Cell Lineage - physiology Cell physiology Fundamental and applied biological sciences. Psychology Genetic Linkage Genetic Variation Hematopoiesis - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Mutant Strains Molecular and cellular biology Nerve Tissue Proteins - genetics Nuclear Proteins - genetics Proto-Oncogene Proteins c-kit - genetics Quantitative Trait, Heritable Recombinant Proteins - genetics |
| title | Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice |
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