Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma

Primary mediastinal large B-cell lymphoma (PMBL), currently recognized as a diffuse large B-cell lymphoma (DLBCL) subtype, shows increased expression of interleukin 4 (IL-4)/IL-13 signaling effectors and targets, suggesting constitutive activation of these pathways. We therefore investigated the fun...

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Veröffentlicht in:	Blood 2004-07, Vol.104 (2), p.543-549
Hauptverfasser:	Guiter, Chrystelle, Dusanter-Fourt, Isabelle, Copie-Bergman, Christiane, Boulland, Marie-Laure, le Gouvello, Sabine, Gaulard, Philippe, Leroy, Karen, Castellano, Flavia
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line, Tumor Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Interleukin-13 - genetics Interleukin-4 - genetics Janus Kinase 2 Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - physiopathology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - physiopathology Mediastinal Neoplasms - metabolism Mediastinal Neoplasms - physiopathology Medical sciences Phosphorylation Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins STAT6 Transcription Factor Trans-Activators - metabolism
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