In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein

Multidrug resistance associated proteins (MRPs) and P-glycoprotein (P-gp) are involved in hepatobiliary transport of various compounds. Our aim was (1) to define transporter specificity of the cholescintigraphic agents 99mTc-HIDA and 99mTc-MIBI, which are used clinically for myocardial perfusion mea...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2004-08, Vol.54 (2), p.131-138
Hauptverfasser:	HENDRIKSE, N. Harry, KUIPERS, Folkert, MEIJER, Coby, HAVINGA, Rick, BIJLEVELD, Charles M. A, VAN DER GRAAF, Winette T. A, VAALBURG, Willem, DE VRIES, Elisabeth G. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacology Bile - secretion Biological and medical sciences Glutathione - metabolism Liver - diagnostic imaging Liver - physiology Male Medical sciences Multidrug Resistance-Associated Proteins - pharmacology Pharmacology. Drug treatments Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Rats Rats, Wistar Technetium - pharmacokinetics Technetium Tc 99m Lidofenin - pharmacokinetics Technetium Tc 99m Sestamibi - pharmacokinetics Tumors
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