Inhibitory Effect of Lamotrigine on A‐type Potassium Current in Hippocampal Neuron–Derived H19‐7 Cells

Purpose: We investigated the effects of lamotrigine (LTG) on the rapidly inactivating A‐type K+ current (IA) in embryonal hippocampal neurons. Methods: The whole‐cell configuration of the patch‐clamp technique was applied to investigate the ion currents in cultured hippocampal neuron–derived H19‐7 c...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2004-07, Vol.45 (7), p.729-736
Hauptverfasser:	Huang, Chin‐Wei, Huang, Chao‐Ching, Liu, Yen‐Chin, Wu, Sheng‐Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Action Potentials - drug effects Action Potentials - physiology Animals Anticonvulsants - pharmacology A‐type K+ current Biological and medical sciences Capsaicin - pharmacology Cell Line Cells, Cultured Dose-Response Relationship, Drug Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampal neurons Hippocampus - cytology Hippocampus - drug effects Hippocampus - embryology Lamotrigine Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Nervous system (semeiology, syndromes) Neurology Neurons - drug effects Neurons - physiology Patch-Clamp Techniques Potassium - physiology Potassium Channel Blockers - pharmacology Potassium Channels - drug effects Potassium Channels - physiology Potassium Channels, Voltage-Gated - drug effects Potassium Channels, Voltage-Gated - physiology Quinidine - pharmacology Rats Rats, Sprague-Dawley Triazines - pharmacology
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