Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis

A strict regulation of hepatocyte growth factor/scatter factor (HGF/SF)-Met signaling is essential for its appropriate function. Several negative regulators of Met signaling have been identified. Here we report that human Spry2 is induced by HGF/SF and negatively regulates HGF/SF-Met signaling. We s...

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Veröffentlicht in:	Oncogene 2004-07, Vol.23 (30), p.5193-5202
Hauptverfasser:	Lee, Chong-Chou, Putnam, Andrew J, Miranti, Cindy K, Gustafson, Margaret, Wang, Ling-Mei, Vande Woude, George F, Gao, Chong-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Biosensing Techniques Biosensors Blotting, Western c-Met protein Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Adhesion Cell Biology Cell cycle Cell Division Cell growth Cell Line, Tumor Cell migration Cell Movement Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Collagen - metabolism Cytokinesis Drug Combinations Fibroblast growth factors Focal Adhesions Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Green Fluorescent Proteins Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - pharmacology Human Genetics Humans Insects Internal Medicine Kinases Laminin - metabolism Leiomyosarcoma - metabolism Leiomyosarcoma - pathology Luminescent Proteins - metabolism Medicine Medicine & Public Health Mitogens - metabolism Mitogens - pharmacology Molecular and cellular biology Neoplasm Invasiveness Nerve Tissue Proteins - metabolism Oncology original-paper Polyploidy Proteins Proteoglycans - metabolism Proto-Oncogene Proteins c-met - metabolism Signal Transduction Stress Fibers Tumors Wound healing
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