An engineered epigenetic transgene switch in mammalian cells

In multicellular systems cell identity is imprinted by epigenetic regulation circuits, which determine the global transcriptome of adult cells in a cell phenotype-specific manner. By combining two repressors, which control each other's expression, we have developed a mammalian epigenetic circui...

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Veröffentlicht in:	Nature biotechnology 2004-07, Vol.22 (7), p.867-870
Hauptverfasser:	Kramer, Beat P, Viretta, Alessandro Usseglio, Aubel, Dominique, Fussenegger, Martin, Weber, Wilfried, Baba, Marie Daoud-El
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Alkaline Phosphatase - analysis Alkaline Phosphatase - biosynthesis Alkaline Phosphatase - genetics Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Transplantation CHO Cells Cricetinae Epigenesis, Genetic - drug effects Epigenesis, Genetic - genetics Erythromycin - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation Gene Silencing - drug effects Genes, Synthetic Genetic Engineering Genetic technics letter Life Sciences Mammals Mathematical models Methods. Procedures. Technologies Mice Modification of gene expression level Pristinamycin - pharmacology Transgenes - genetics
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